Bas WM van Balkom,
Assistant Professor,
University Medical Center Utrecht
Dr van Balkom is an assistant professor in the Dept of Nephrology and Hypertension, UMC Utrecht, The Netherlands, which is part of the Regenerative Medicine Center Utrecht. His main research interest lies in the exploration of extracellular vesicle (EV) content and function, applied in the setting of (chronic) kidney disease. He particularly focusses on the potential application of EVs for diagnostic and therapeutic purposes.
A Human Kidney and Liver Organoid-based Organ-on-a-chip Model to Study the Therapeutic Effects and Biodistribution of Mesenchymal Stromal Cell-derived Extracellular Vesicles
Monday, 24 October 2022 at 12:00
Add to Calendar ▼2022-10-24 12:00:002022-10-24 13:00:00Europe/LondonA Human Kidney and Liver Organoid-based Organ-on-a-chip Model to Study the Therapeutic Effects and Biodistribution of Mesenchymal Stromal Cell-derived Extracellular VesiclesBioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Mesenchymal stromal cell (MSC)-derived small EVs (sEVs) show therapeutic potential in multiple disease models, including kidney injury. Clinical translation of sEVs requires further preclinical and regulatory developments, like elucidation of the mode of action (MoA) and formulation of safety and release criteria. sEVs tend to accumulate in the liver and at sites of injury. Biodistribution knowledge is crucial to assess MoA, efficacy and safety, and can be obtained using labelled sEVs in animal models, which come with ethical concerns, are time-consuming and expensive, and do not represent all human physiological processes equally well. We developed an organoid-based organ-on-a-chip model to assess the efficacy and biodistribution of these sEVs. The human background allows for in-depth analysis of the MoA and identification of potential side effects and accelerated development of EV-based therapeutics.
Add to Calendar ▼2022-10-24 00:00:002022-10-25 00:00:00Europe/LondonBioengineering for Building Microphysiological Systems 2022Bioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2022-10-24 12:00:002022-10-24 13:00:00Europe/LondonA Human Kidney and Liver Organoid-based Organ-on-a-chip Model to Study the Therapeutic Effects and Biodistribution of Mesenchymal Stromal Cell-derived Extracellular VesiclesBioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
