Vincenzo Pucci,
Principal Scientist, Preclinical Bioanalytical Group,
Merck Research Laboratories
Dr. Vincenzo Pucci is the Principal Scientist of the Preclinical Bioanalytical Group at Merck Research Laboratories in Boston, Massachusetts. He holds a PhD in Pharmaceutical Science and MSc and BSc degrees in Pharmaceutical Chemistry and Technology from the University of Bologna (Italy). During his research assistant fellowship years he developed several analytical methods for therapeutic drug monitoring of antipsychotics in collaboration with the Institute for Analytical Chemistry, University of Vienna (Austria) and the Department of Chemistry, University of California in Berkeley. He joined Merck in 2004 as Research Chemist within the DMPK department at IRBM in Italy and from 2009 leads the bioanalytical group of Boston MRL conducting small molecule quantitative bioanalysis of PK and PK/PD samples to support candidate selection as part of drug discovery programs. His major research interests include lab automation, sample preparation methodologies and utilization of novel HPLC and LC-MS/MS approaches in bioanalysis.
Bioanalytical Sample Preparation Strategies Prior to LC-MS/MS Analysis of Drugs and Biomarkers
Wednesday, 30 September 2015 at 16:00
Add to Calendar ▼2015-09-30 16:00:002015-09-30 17:00:00Europe/LondonBioanalytical Sample Preparation Strategies Prior to LC-MS/MS Analysis of Drugs and BiomarkersNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
An essential component of the drug-discovery process is the
determination of drug and biomarker concentrations in biological samples
which yields the data necessary to understand the pharmacokinetics and
pharmacodynamic, respectively. To obtain these data, each sample of
fluid obtained from an in vitro or in vivo study is subjected to sample
preparation, chromatographic separation, and analytical detection.
Sample preparation is an important and necessary step in the overall
analytical process, because most analytical instruments cannot accept
the sample matrix directly. Despite the tremendous advances in liquid
chromatography mass spectrometry (LC-MS) and LC tandem mass spectrometry
(LC-MS/MS) detection systems in recent times, sample preparation still
represents the most challenging part of the bioanalytical workflow. The
removal of unwanted endogenous matrix components (e.g., protein, salts,
etc.) from the sample must be rapid and as complete as possible to avoid
the introduction of interferences upon analysis. Many different
techniques are available to a drug discovery scientist performing
bioanalytical sample preparation. The focus of this presentation is to
introduce the goals for sample preparation and the many choices
available to the drug-discovery scientist.
Add to Calendar ▼2015-09-28 00:00:002015-09-30 00:00:00Europe/LondonNGS, SCA, Mass Spec: The Road to DiagnosticsNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-09-30 16:00:002015-09-30 17:00:00Europe/LondonBioanalytical Sample Preparation Strategies Prior to LC-MS/MS Analysis of Drugs and BiomarkersNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
