Stephen C. Jacobson received a B.S. in mathematics from Georgetown University in 1988 and a Ph.D. in chemistry from the University of Tennessee in 1992. After graduate school, Stephen was awarded an Alexander Hollaender Distinguished Postdoctoral Fellowship at Oak Ridge National Laboratory (ORNL), and in 1995, he became a research staff member at ORNL. In 2003, Stephen joined the faculty at Indiana University and is a professor in the Department of Chemistry. His research efforts are directed toward miniaturization of analytical instrumentation with an emphasis on micro- and nanofluidic devices. Stephen and his research group are currently working in the areas of microfluidic separations, nanofluidic transport, cancer screening, virus sensing, and bacterial adhesion and aging.
Tracking Development and Aging of Individual Bacteria with Microfluidic Devices
Tuesday, 29 September 2015 at 11:00
Add to Calendar ▼2015-09-29 11:00:002015-09-29 12:00:00Europe/LondonTracking Development and Aging of Individual Bacteria with Microfluidic DevicesNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Analysis of single cells provides powerful insight into biological processes that are often missed when a population of cells is studied as an ensemble. We are developing microfluidic-based approaches coupled with optical microscopy to track individual bacteria and to improve the temporal and spatial resolution of single-cell measurements. To streamline our experiments, we designed and tested a microfluidic “baby machine,” which automates the culture, synchronization, and analysis steps. This microfluidic device is used to produce synchronized populations of cells and monitor adhesion of individual bacteria to surfaces. To study development and aging in bacteria, we integrated nanochannel arrays into the microfluidic platform that physically trap bacteria. With these nanochannel arrays, we are able to study a number of bacteria strains and observe them over multiple generations. Consequently, we are able to determine rates of cell growth and division, monitor accumulation of cellular damage, and observe epigenetic effects.
Add to Calendar ▼2015-09-28 00:00:002015-09-30 00:00:00Europe/LondonNGS, SCA, Mass Spec: The Road to DiagnosticsNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-09-29 11:00:002015-09-29 12:00:00Europe/LondonTracking Development and Aging of Individual Bacteria with Microfluidic DevicesNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
