Xin Ding's Biography

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Bacterial Membrane Vesicles-Inspired Antimicrobial Drug Delivery Systems and Vaccines

Saturday, 21 November 2026 at 14:00

Add to Calendar ▼2026-11-21 14:00:002026-11-21 15:00:00Europe/LondonBacterial Membrane Vesicles-Inspired Antimicrobial Drug Delivery Systems and VaccinesNanomedicine and LNPs Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com

Multidrug-resistant bacterial infections pose a critical threat to global health, demanding innovative antimicrobial strategies. Biological barriers – including biofilms and the dual-membrane architecture of Gram-negative bacteria – fundamentally limit intracellular drug delivery. Capitalizing on the innate cell-penetrating capacity of outer membrane vesicles (OMVs), we engineered three targeted therapeutic platforms: 1. OMV-based antimicrobial delivery systems that efficiently transport repurposed rifampicin to homologous Gram-negative pathogens, establishing a novel drug rediscovery paradigm; 2. Hybrid membrane vesicles (HMVs) integrating neutrophil membranes with OMVs to simultaneously neutralize LPS toxicity and confer infection microenvironment-targeting capability, achieving dual-pathogen eradication in systemic and pulmonary infections; 3. Multiantigenic nanovaccines fabricated by fusing OMVs with bacterial antigen-adsorbed macrophage membranes, which eliminate pathogens through direct bacteriolysis and toxin neutralization, yielding 100% survival in sepsis models and >99.9% bacterial clearance in pneumonia. Collectively, our engineered vesicle platforms overcome fundamental delivery barriers, transforming OMVs from biological components into robust therapeutic pipelines against intractable Gram-negative infections.