Generation of iPSC-derived 3D Neurospheres for Modeling Retroviral Infection and EV-mediated RepairWednesday, 15 December 2021 at 16:30 Add to Calendar ▼2021-12-15 16:30:002021-12-15 17:30:00Europe/LondonGeneration of iPSC-derived 3D Neurospheres for Modeling Retroviral Infection and EV-mediated RepairOrganoids and Organs-on-Chips 2021 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com We report the generation of iPSC-derived neurospheres and show that these cultures are permissive to HIV-1 infection. In addition, we examine the functional effects of stem cell extracellular vesicles (EVs) on HIV-1 infected neurospheres. Our data demonstrates the feasibility of iPSC-derived neurospheres for modeling HIV-1 infection and highlights the potential of stem cell EVs for rescuing cellular damage. |