Andries D. van der Meer,
Associate Professor, Scientific lead, Organ-on-Chip Center Twente,
University of Twente
Dr. Andries D. van der Meer is Associate Professor at the Faculty of Science and Technology of the University of Twente, The Netherlands. He is leader of the research theme ‘Organs-on-Chips’ in the Applied Stem Cell Technologies group of the Bioengineering Technologies cluster, supervising five Ph.D. candidates and coordinating multiple research projects on the development of blood vessels-on-chips as well as their integration in full organ-on-chip systems like the retina-on-chip, lung-on-chip and heart-on-chip.
From 2013 to 2015, Dr. Van der Meer worked as a Senior Research Fellow at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering of Harvard University, Cambridge, MA, USA. He actively developed organ-on-chip models of the blood-brain barrier and the alveolus for the Defense Advanced Research Projects Agency (DARPA) Microphysiological Systems program and coordinated a collaborative project between the Wyss Institute organ-on-chip start-up company Emulate, Inc. and Janssen Pharmaceuticals. Before joining Harvard University, he was a Post-Doctoral Fellow at Prof. Albert van den Berg’s BIOS/Lab-on-a-Chip group of the University of Twente, The Netherlands. During that time, he also served as an Assistant Coordinator for the project ‘Beyond Borders: Organs-on-Chips’ of the Dutch Royal Academy (KNAW). This project led to the founding of the Dutch Human Organ and Disease Model Technologies (hDMT) Organ-on-Chip consortium, for which Dr. Van der Meer is his university’s representative.
Dr. Van der Meer obtained his Ph.D. in Biomedical Engineering from the University of Twente, The Netherlands in 2010, and received his M.Sc. degree in Medical Biology from the University of Groningen, The Netherlands in 2005.
Blood Vessels-on-Chips
Wednesday, 9 September 2020 at 16:30
Add to Calendar ▼2020-09-09 16:30:002020-09-09 17:30:00Europe/LondonBlood Vessels-on-ChipsOrgan-on-a-Chip, Tissue-on-a-Chip and Organoids Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
The total surface area of blood vessel wall in the human body is more than 1,000 m2, equal to more than five tennis courts. The vessel wall is not simply a physical barrier between blood and surrounding tissue, it is also a remarkably plastic structure, which plays a key role in the pathophysiology of many diseases. Organs-on-chips are ideal platforms to model blood vessel biology in vitro, because they allow researchers to set defined and dynamic patterns of flow, pressure, geometry and levels of oxygen, all of which are essential aspects of blood vessel physiology. Moreover, organs-on-chips enable the controlled co-culture between blood vessel tissue and neighboring tissues and matrices, ultimately allowing studies of disease mechanisms. In this talk, I will show how blood vessel tissue, primarily endothelial cells, can be integrated in organs-on-chips to realistically mimic blood vessel physiology. Moreover, I will show how exposing these blood vessels to activating stimuli, like inflammatory cytokines, can induce vascular adhesion molecule expression, vascular leakage and thrombosis. Finally, I will discuss how organ-on-chip technology allows the engineering of ‘personalized’ in vitro models of blood vessels by mimicking 3D vessel structures based on medical imaging, perfusion of blood samples spiked with disease-related cytokines and incorporation of vascular tissue derived from human induced pluripotent stem cells.
Add to Calendar ▼2020-09-09 00:00:002020-09-10 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip and Organoids Europe 2020Organ-on-a-Chip, Tissue-on-a-Chip and Organoids Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2020-09-09 16:30:002020-09-09 17:30:00Europe/LondonBlood Vessels-on-ChipsOrgan-on-a-Chip, Tissue-on-a-Chip and Organoids Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
