Yan Yan Shery Huang,
Professor of BioEngineering,
University of Cambridge
Dr. Huang is Professor of BioEngineering, University of Cambridge. She completed her MEng degree in Materials Science and Engineering from Imperial College London in 2007. She then pursued a PhD in Physics at Cambridge. She was a visiting researcher at University of Texas at Austin (2008), and an Oppenheimer Fellow and a Homerton College Junior Research Fellow (2011-2013). She is a recipient of the prestigious ERC Starting grant, and a fellow of the Institute of Fellow of the Institute of Materials, Minerals and Mining, UK.
Deployable Extrusion Bioprinting of Compartmental Tumoroids with Cancer Associated Fibroblasts for Immune Cell Interactions
Tuesday, 20 June 2023 at 12:00
Add to Calendar ▼2023-06-20 12:00:002023-06-20 13:00:00Europe/LondonDeployable Extrusion Bioprinting of Compartmental Tumoroids with Cancer Associated Fibroblasts for Immune Cell InteractionsOrganoids and Spheroids Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Realizing the translational impacts of three-dimensional (3D) bioprinting for cancer research necessitates innovation in bioprinting workflows which integrate affordability, user-friendliness, and biological relevance. Herein, we demonstrate 'BioArm', a simple, yet highly effective extrusion bioprinting platform, which can be folded into a carry-on pack, and rapidly deployed between bio-facilities. BioArm enabled the reconstruction of compartmental tumoroids with cancer-associated fibroblasts (CAFs), forming the shell of each tumoroid. The 3D printed core–shell tumoroids showed de novo synthesized extracellular matrices, and enhanced cellular proliferation compared to the tumour alone 3D printed spheroid culture. Further, the in vivo phenotypes of CAFs normally lost after conventional 2D co-culture re-emerged in the bioprinted model. Embedding the 3D printed tumoroids in an immune cell-laden collagen matrix permitted tracking of the interaction between immune cells and tumoroids, and subsequent simulated immunotherapy treatments. Our deployable extrusion bioprinting workflow could significantly widen the accessibility of 3D bioprinting for replicating multi-compartmental architectures of tumour microenvironment, and for developing strategies in cancer drug testing in the future.
Add to Calendar ▼2023-06-19 00:00:002023-06-20 00:00:00Europe/LondonOrganoids and Spheroids Europe 2023Organoids and Spheroids Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2023-06-20 12:00:002023-06-20 13:00:00Europe/LondonDeployable Extrusion Bioprinting of Compartmental Tumoroids with Cancer Associated Fibroblasts for Immune Cell InteractionsOrganoids and Spheroids Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
