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SELECTBIO Conferences Organ-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo Functions

Megan L McCain's Biography



Megan L McCain, Assistant Professor of Biomedical Engineering and Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine

Megan L. McCain, PhD, is the Chonette Early Career Chair and Assistant Professor in the Department of Biomedical Engineering at USC Viterbi School of Engineering and Stem Cell Biology and Regenerative Medicine at Keck School of Medicine of USC. Her research group, the Laboratory for Living Systems Engineering, engineers microscale mimics of human tissues, known as “Organs on Chips”. They implement these platforms to characterize human disease progression and identify promising therapeutic strategies on a personalized basis, with a focus on cardiac and skeletal muscle diseases. They also work closely with pharmaceutical companies to translate their platforms for next-generation pre-clinical drug screening. Megan is a recipient of a Scientist Development Grant from the American Heart Association and an Innovation Award from the Eli and Edythe Broad Foundation. She has also been recognized as a Top Innovator Under 35 by MIT Technology Review and a Young Innovator in Cellular and Molecular Bioengineering by the Biomedical Engineering Society. She received her PhD and postdoctoral training in Engineering Sciences from Harvard University.

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Engineering Microphysiological Models of Human Cardiac and Skeletal Muscle Disease

Monday, 10 July 2017 at 13:30

Add to Calendar ▼2017-07-10 13:30:002017-07-10 14:30:00Europe/LondonEngineering Microphysiological Models of Human Cardiac and Skeletal Muscle DiseaseSELECTBIOenquiries@selectbiosciences.com

Cardiovascular diseases are the leading cause of death in the United States. One reason for this statistic is that researchers in academia and industry have been forced to rely on experimental models, such as rodents or simplified cell culture systems, that lack relevance to native human heart tissue. In this talk, I will describe our efforts in engineering microphysiological models of human cardiac tissue as next-generation platforms for cardiac disease modeling and drug screening. We are focused on developing and integrating three core technologies: (1) Enhancing the differentiation of human induced pluripotent stem cells (hiPSCs) into cardiac myocytes; (2) Engineering cellular microenvironments that mimic key features of native cardiac tissue; and (3) Developing quantitative assays for characterizing essential functional outputs, such as contractility. I will also describe how we have extended our technologies to skeletal muscle tissue as new platforms for modeling human skeletal myopathies. Together, these microphysiological models of human striated muscle tissue have many applications in establishing human disease mechanisms and screening the functional effects of drugs with disease and patient specificity.


Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonOrgan-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo FunctionsSELECTBIOenquiries@selectbiosciences.com