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SELECTBIO Conferences Organ-on-a-Chip and 3D-Culture: Companies, Technologies and Approaches

Andreas Schober's Biography

Andreas Schober, Head of Department Nano-biosystem Technology, University of Technology Ilmenau, Technische Universitat Ilmenau

Andreas Schober is Professor at Department of Nano-Biosystem Technology (NBST) at the Technische Universität Ilmenau. He received his Ph.D. (1994) from Max-Planck Institute for Biophysical Chemistry Göttingen and habilitation (2002) from Institute for Nano-Biotechnology, University of Natural Resources and Life Science Vienna. Before joining Ilmenau University of Technology in 2004 he acted almost 10 years as project and group leader at research institutes and industry (Institute of Molecular Biotechnology, Jena (1994-97) and Merck KGaA, Darmstadt/ IPHT, Jena (1997-2003)). In 2004 he joined TU-Ilmenau. He was awarded two Junior research groups and headed in addition many research grants for developing systems for microfluidic and 3D-cell cultivation. He acted as head of the nanotechnology group and as temporary Professor (2007 – 2011). Since 2011 he obtained full professor position at TU-Ilmenau. His research interest is focused in the last years on biological systems and their emulation within the frameworks of Biotechnical Multi-scale Engineering (BME). Applications of BME range from the Life Sciences to Medical and Biotechnology.
He started his career within the context of evolutionary biotechnology developing online PCR facilities and nanofluidic drop-on-demand devices for biotechnical applications. During several industrial cofounded projects he became interested in 3D cell cultivation for application in the pharmaceutical industry. His group is an interdisciplinary team focusing on the development of micro reactors especially micro bioreactors including new 3D supports for the 3D cultivation and analysis of cells e.g. gene expression analysis. He is author of more than 120 publications and more than 40 patent applications.

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BioLithoMorphie®: A Method for the Construction of 3D Biological Morphologies

Tuesday, 11 July 2017 at 12:00

Add to Calendar ▼2017-07-11 12:00:002017-07-11 13:00:00Europe/LondonBioLithoMorphie®: A Method for the Construction of 3D Biological

Recent advances in the “life Sciences” related to organ -on-a chip, tissue engineering and pharmaceutical drug testing etc. will need methods to guide the assembly of cells in 3D. In this contribution we will explain our approach to gain complex cellular structures while using different polymers and biopolymers processed by micromachining, chemical pattern guided cell cultivation, photo polymerization, and organ printing methods. Such a “toolbox” transferring methods from microsystem technology and surface chemistry for the production of 3-dimensional biological morphologies could be defined as BioLithoMorphie®. By retrieving the main geometric features of a biological morphology on different geometric scales (biotechnical multiscale engineering) we are able to define the most important parameters to mimic complex tissue like structures of different organs . Due to folding and stacking of pre manufactured polymers (cell sheet layers) it is also possible to achieve tissue like structures including fluidic entities, e.g. to emulate the complete structure of liver lobules. Another promising approach is mimicking the morphologies of the blood stem cell niche. Experiments indicate that it is possible to maintain the stem cell characteristics of blood stem cells during proliferation in manufactured polymer foils of the bone marrow. This might be a breakthrough to get the chance for amplifying the number of stem cells for transplantation also in the treatment of leukemia.

Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonOrgan-on-a-Chip and 3D-Culture: Companies, Technologies and