Lab-on-Chip Devices For Analysis of Extracellular Vesicles and Their Contents From Cerebral Organoid TissueTuesday, 19 November 2024 at 11:00 Add to Calendar ▼2024-11-19 11:00:002024-11-19 12:00:00Europe/LondonLab-on-Chip Devices For Analysis of Extracellular Vesicles and Their Contents From Cerebral Organoid TissueOrganoids, Spheroids and Organs-on-Chips 2024 in Laguna Hills, CaliforniaLaguna Hills, CaliforniaSELECTBIOenquiries@selectbiosciences.com Cultured organoids have emerged as important test beds for studying cell development and disease. Sub-micron sized extracellular vesicles (EVs), including exosomes, secreted by these organoids provide an ideal opportunity for assessing and continuously monitoring organoid status on the molecular level. I will describe the development of integrated lab-on-chip devices for real-time analysis of EVs produced in a custom 3D cerebral organoid tissue culture platform. This includes the detection of individual exosomes as well as their molecular biomarker cargo using single particle fluorescence and trapping-assisted nanopore sensing. I will also discuss the direct incorporation of this electro-optofluidic lab-on-chip within the tissue culture platform. |