Alexander Asanov,
Chief Scientific Officer,
TIRF Labs, Inc.
Before founding TIRF Labs in 2004, Dr. Asanov held academic positions at the Institute of Chemical Physics, Russian Academy of Sciences (RAS), the University of Alabama at Birmingham, and Mississippi State University. He received M.S. degree in Biophysics from the Moscow Institute for Physics and Technology, and Ph.D. degree in Chemical Physics from the Institute of Chemical Physics, RAS. His Ph.D. advisor was Nobel Prize laureate academician N. N. Semenov. In the period 2004-2011 Dr. Asanov served as the Principal Investigator on several BAA and SBIR projects sponsored by the U.S. government through the National Institutes of Health and the U.S. Homeland Security Advanced Research Projects Agency (HSARPA).
The Cellphone Future of Precision Medicine: Enhanced TIRF Microarrays for Accurate and Rapid iDiagnostics
Wednesday, 30 September 2015 at 16:00
Add to Calendar ▼2015-09-30 16:00:002015-09-30 17:00:00Europe/LondonThe Cellphone Future of Precision Medicine: Enhanced TIRF Microarrays for Accurate and Rapid iDiagnosticsPoint-of-Care Diagnostics and Global Health World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
There are over 7 billion cellphone users in the world. Most of the cellphones are equipped with numerous sensors, powerful computers, and high resolution CCD cameras. Cellphones have changed the landscape of many technological areas. Their capabilities can be employed for home-use precision diagnostics, as well as point-of-care applications. Cellphone-based diagnostics offers numerous opportunities for improving the health care. In this talk, I will present a novel cellphone-based platform technology, termed iDiagnostics, which is capable of detecting protein, nucleic acid, and metabolite biomarkers simultaneously, in real-time mode, using a droplet of blood, saliva, urine, or other biofluids. The technology is based on Total Internal Reflection Fluorescence (TIRF) and is rapid, supersensitive, and multiplexed, which allows for precision diagnosing and accurate prognosing. Yet, iDiagnostics is inexpensive. The cradle will cost $200-$300, and disposable cartridges $1-5, if manufactured massively. iDiagnostics microarray employs a silk fibroin self-assembled nanometer-scale structure, which implements several functions. Firstly, silk fibroin film captures the excitation light from the TIRF lightguide and allows for much greater immobilization of affinity reagents at the surface of TIRF sensor chip. Since the resulting signal is a thousand-fold greater than that with classical TIRF, sensitivity of cellphone CCD cameras is sufficient for detection. Secondly, silk fibroin scaffold provides biologically-friendly environment for bioassay immobilization, preserving their activity after immobilization. Thirdly, silk-encapsulation prolongs shelf life of antibodies and other biological compounds, a feature which is important for diagnostics in low resources settings. High sensitivity and broad dynamic range of iDiagnostics allows for detecting the entire range of clinically significant biomarkers.
Add to Calendar ▼2015-09-28 00:00:002015-09-30 00:00:00Europe/LondonPoint-of-Care Diagnostics and Global Health World CongressPoint-of-Care Diagnostics and Global Health World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-09-30 16:00:002015-09-30 17:00:00Europe/LondonThe Cellphone Future of Precision Medicine: Enhanced TIRF Microarrays for Accurate and Rapid iDiagnosticsPoint-of-Care Diagnostics and Global Health World Congress in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
