Michael Schöning,
Professor and Director, Institute of Nano- and Biotechnologies,
Aachen University of Applied Sciences
Michael J. Schöning received his diploma degree in electrical engineering (1989) and his PhD in the field of semiconductor-based microsensors for the detection of ions in liquids (1993), both from the Karlsruhe University of Technology. In 1989, he joined the Institute of Radiochemistry at the Research Centre Karlsruhe. Since 1993, he has been with the Institute of Thin Films and Interfaces (now, Peter Grünberg Institute, PGI-8) at the Research Centre Jülich, and since 1999 he was appointed as full professor at Aachen University of Applied Sciences, Campus Jülich. Since 2006, he serves as a director of the Institute of Nano- and Biotechnologies (INB) at the Aachen University of Applied Sciences. His main research subjects concern silicon-based chemical and biological sensors, thin-film technologies, solid-state physics, microsystem and nano(bio-)technology.
Enzymatic Biosensor to Support the Diagnosis of Adrenal Gland Tumors
Wednesday, 19 June 2019 at 16:15
Add to Calendar ▼2019-06-19 16:15:002019-06-19 17:15:00Europe/LondonEnzymatic Biosensor to Support the Diagnosis of Adrenal Gland TumorsPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Primary aldosteronism (PA) is a disorder in which aldosterone production is inappropriately high and causes hypertension. The clinical guidelines advocate using adrenal vein sampling (AVS) to diagnose PA. However, since AVS is a demanding procedure in which correct cannulation of adrenal veins is challenging, it is used only in a few centers worldwide. To facilitate this medical examination, the detection of adrenaline during AVS could be used as an indicator for the correct position of the catheter, since the adrenaline concentration in adrenal blood (100 nM) is about 100 times higher in comparison to peripheral blood (1 nM).
Two different biosensor approaches for the detection of adrenaline will be presented, which are based on the substrate recycling principle. The first variant is based on an amperometric bi-enzyme biosensor with a genetically modified laccase and a glucose dehydrogenase (GDH). The second example represents a chip-based biosensor with the enzyme PQQ-GDH. Both sensor types have been optimized under laboratory conditions and successfully applied for first measurements in real blood samples, to define an appropriate catheter position.
Add to Calendar ▼2019-06-18 00:00:002019-06-19 00:00:00Europe/LondonPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019Point-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-06-19 16:15:002019-06-19 17:15:00Europe/LondonEnzymatic Biosensor to Support the Diagnosis of Adrenal Gland TumorsPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
