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SELECTBIO Conferences The RNA Summit: Research, Diagnostics & Therapeutics

Alexei Korennykh's Biography

Alexei Korennykh, Associate Professor, Princeton University

My long-term goal is to define how mammalian cells recognize and cleave non-coding RNA to maintain homeostasis and control their fate under normal conditions, during physiologic stresses, and in diseases. Present efforts in my laboratory focus on stress-activated RNA decay mediated by the human protein kinase/endoribonuclease RNase L, and by sensors of double-stranded RNA (dsRNA) that activate RNase L. The pathway of RNase L inhibits viral and bacterial infections, so major efforts in the field focus on the roles of RNase L in pathogen defense. RNase L is also a potent suppressor of proliferation, and a candidate tumor suppressor, which make RNase L-mediated RNA cleavage a mechanistically unique target for diagnostics and treatments of neoplastic and infectious diseases. To elucidate the biology of RNase L, we use biophysical, structural and genomic methods. My areas of training include protein/RNA recognition, protein kinase structure and function, cell biology, and macromolecular structure analysis. The unique advantage of our group, and a key innovative aspect of our work, is in applying our background in molecular mechanisms to an area of the human innate immune system, which lacks precise mechanistic understanding. Our work aims to address limitations in the field by obtaining a detailed structural and molecular understanding of the key proteins and protein complexes involved in RNA cleavage by RNase L, and by mapping the pathway of mammalian gene regulation by this receptor.

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RNA Cleavage at the Leading Edge of the Innate Immune Response

Tuesday, 14 November 2017 at 11:30

Add to Calendar ▼2017-11-14 11:30:002017-11-14 12:30:00Europe/LondonRNA Cleavage at the Leading Edge of the Innate Immune ResponseThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston,

Why do cells activate RNA cleavage during the interferon (IFN) response? Whereas many intuitive explanations converge on a simple model of RNA degradation as a strategy to slow down and eliminate damaged/infected cells, recent data from others and from our group point to signaling mechanisms that reshape cellular programs. Using structural biology we are learning about regulation of this pathway, whereas a variety of RNA-Seq methods tell us about its specific coding and non-coding RNA targets, leading to the elusive cellular roles of the attack on cell’s RNA from within.

Add to Calendar ▼2017-11-13 00:00:002017-11-14 00:00:00Europe/LondonThe RNA Summit: Research, Diagnostics and TherapeuticsThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston,