Defining Translation in “Noncoding” Regions Using Ribosome ProfilingTuesday, 14 November 2017 at 16:00  Add to Calendar ▼2017-11-14 16:00:002017-11-14 17:00:00Europe/LondonDefining Translation in “Noncoding” Regions Using Ribosome ProfilingThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.comCharacterizing protein coding regions across genomes is fundamentally important for understanding gene regulation and the regulation of RNA translation. Ribosome profiling reveals active translation genome-wide at single nucleotide resolution. We developed a computational pipeline named RibORF and revealed pervasive translation outside of canonical protein coding regions. Over 40% of annotated lncRNAs and pseudogene RNAs, and 35% of 5' UTRs in mRNAs are actively translated. Some peptides encoded by the non-canonical translation events are under stabilizing selection during evolution, and are likely to have biological functions. I will discuss their dynamic regulation and functional importance in cancers. |
Add to Calendar ▼2017-11-13 00:00:002017-11-14 00:00:00Europe/LondonThe RNA Summit: Research, Diagnostics and TherapeuticsThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
