In Vivo Chitosan/siRNA Nanoparticles Specific Targeting and Knockdown in Proximal Tubular Epithelial Cells in Kidney via Megalin Mediated PathwayFriday, 9 September 2011 at 11:15  Add to Calendar ▼2011-09-09 11:15:002011-09-09 12:15:00Europe/LondonIn Vivo Chitosan/siRNA Nanoparticles Specific Targeting and Knockdown in Proximal Tubular Epithelial Cells in Kidney via Megalin Mediated PathwayRNAi and miRNA Europe in MunichMunichSELECTBIOenquiries@selectbiosciences.comSpecific accumulation of chitosan/siRNA demonstrated in mouse kidney by Northern blot and bioimaging; localization of siRNA was at PTECs; particles were only in megalin-expressing cells in megalin conditional-knockout mice, indicating uptake via a megalin-dependent pathway; aquaporin1 was silenced in mice. |
Add to Calendar ▼2011-09-08 00:00:002011-09-09 00:00:00Europe/LondonRNAi and miRNA EuropeRNAi and miRNA Europe in MunichMunichSELECTBIOenquiries@selectbiosciences.com
