Analysis of the Accessibility of PAR-CLIP Bound Sites Reveals that Nucleation of the miRNA:mRNA Pairing Occurs Preferentially at the 3'-end of the Seed MatchTuesday, 4 September 2012 at 16:30 Add to Calendar ▼2012-09-04 16:30:002012-09-04 17:30:00Europe/LondonAnalysis of the Accessibility of PAR-CLIP Bound Sites Reveals that Nucleation of the miRNA:mRNA Pairing Occurs Preferentially at the 3'-end of the Seed MatchSELECTBIOenquiries@selectbiosciences.com Detailed analysis of PAR-CLIP miRNA binding sites demonstrates that miRNA target binding starts preferentially at the 3' end of the seed match. Complementary analysis of mRNA and protein levels shows that genes with accessible nucleation regions at the 3'-end are more strongly downregulated than other genes. |