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SELECTBIO Conferences Exosomes & Single Cell Analysis Summit

Michael Graner's Biography

Michael Graner, Associate Professor, Dept of Neurosurgery, University of Colorado Anschutz School of Medicine

Michael Graner received his PhD in Biochemistry from the University of Illinois followed by post-doctoral and research faculty work at the University of Arizona, shifting gears from the Drosophila extracellular matrix to cancer immunotherapy. He then took at faculty position at Duke University’s Tisch Brain Tumor Center, followed by his current position as an Associate Professor in Neurosurgery at the University of Colorado Denver (Anschutz Medical Campus). He is also a member of the University of Colorado Cancer Center, the Colorado Clinical and Translational Sciences Institute, the MAVRC Program, and holds a Visiting Professorship Appointment at the Shenzhen Third People’s Hospital (China) and an adjunct faculty appointment at Colorado State University. Graner has a long-standing interest in cell stress responses, which led to cancer vaccine development (including one in clinical trials), which somehow led to the world of extracellular vesicles (EVs). His lab currently concentrates on signaling mechanisms involving EVs, in particular the transfer of stressed phenotypes from stressed tumor cells to unstressed ones via EVs.

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Extracellular Vesicles in Cancer Signaling Pathways

Friday, 19 September 2014 at 16:45

Add to Calendar ▼2014-09-19 16:45:002014-09-19 17:45:00Europe/LondonExtracellular Vesicles in Cancer Signaling PathwaysExosomes and Single Cell Analysis Summit in San Diego, California, USASan Diego, California,

Extracellular vesicles (EVs) are virus-sized membrane-enclosed vesicles that are released by cells via various mechanisms. Their contents reflect the molecular make-up of their cells of origin, and thus EVs show potential as biomarkers. EVs also serve as packets of signal initiators and transducers with effects proximal and distal to their release. Here we show that EVs from brain tumor cells have profound impacts on recipient cells (both tumor cells and normal cells) in terms of proteomic changes and induced signaling cascades. Most of these changes can be regarded as benefiting the tumor. The abilities of EVs to influence phenotypes and activities of recipient cells are likely among the most important functions of EVs. In a tumor setting, this knowledge may help us design better therapeutic strategies based on a continuous dynamic rather than static assumptions about the status of a cancer.

Add to Calendar ▼2014-09-18 00:00:002014-09-19 00:00:00Europe/LondonExosomes and Single Cell Analysis SummitExosomes and Single Cell Analysis Summit in San Diego, California, USASan Diego, California,