Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences RNA-Seq, Single Cell Analysis & Single Molecule Analysis 2017

Sara Linker's Biography



Sara Linker, Staff Scientist, Lab of Fred H. Gage, Laboratory of Genetics, The Salk Institute for Biological Studies

Sara Linker received her Ph.D. from the Hussman Institute for Human Genomics at the University of Miami in 2014 where she studied the impact of mobile element insertions on the human genome. She then joined the lab of Dr. Fred H. Gage at the Salk Institute as a postdoctoral fellow in 2014 and began working on multiple projects including examining activity-induced expression in hippocampal nuclei using single-nucleus RNA-sequencing. She is currently interested in using single-nucleus methods to explore the endogenous heterogeneity between neurons, at both the level of RNA and DNA, and how that heterogeneity impacts broader behavioral phenotypes.

Sara Linker Image

Single-Nucleus RNA-Seq Reveals Unique Transcriptional Response in the Dentate Gyrus in Response to Hippocampal Activation

Friday, 6 October 2017 at 17:00

Add to Calendar ▼2017-10-06 17:00:002017-10-06 18:00:00Europe/LondonSingle-Nucleus RNA-Seq Reveals Unique Transcriptional Response in the Dentate Gyrus in Response to Hippocampal ActivationRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

We performed single-nucleus sequencing of glutamatergic and GABAergic neurons from the hippocampus after a mouse was exposed to novelty for 15 minutes. We identified that recently active neurons, expressing FOS protein, generated an activity-induced transcriptome that was highly dependent on cell type and dentate granule cells were the most transcriptionally responsive.


Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017RNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com