Bart Westendorp's Biography

Bart Westendorp, Assistant Professor, Faculty of Veterinary Medicine, Utrecht University The Netherlands

Bart Westendorp is Assistant Professor at Utrecht University, The Netherlands. His primary research interest is to understand how decision-making is done in cells during normal cell division, cell stress, development, and cancer. He combines live cell imaging techniques with (single cell) transcriptomics to address this topic. Within the Department of Pathobiology he has focused on the functions and regulation of the E2F transcription factor family. This family of proteins acts in the center of the gene regulation machinery that controls cell division and tissue development. In 2015, Bart Westendorp has established the Single Cell Analysis Center, a research facility within Utrecht University for the genomic and transcriptomic analysis of single cells.

Single-Cell Dissection of Gene Transcription Regulation Networks that Control Cell Cycle Decisions and Cell Fates after DNA Damage

Thursday, 5 October 2017 at 15:00

Add to Calendar ▼2017-10-05 15:00:002017-10-05 16:00:00Europe/LondonSingle-Cell Dissection of Gene Transcription Regulation Networks that Control Cell Cycle Decisions and Cell Fates after DNA DamageRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

The faithful replication of DNA during each cell division is essential, because uncorrected DNA errors can severely disturb cell function and ultimately lead to cancer. In response to DNA damage mammalian cells have a variety of mechanisms to either repair DNA, enter alternative cell cycle fates, or undergo programmed cell death. Individual cell fate thus depends on the decision which of these mechanisms is activated. Using a combination of single-cell RNA-sequencing and live cell imaging, we are now able to investigate in unprecedented detail how cells coordinate the transcriptional response to DNA damage. We begin to understand which gene regulation networks determine cell fates and therapy resistance of cancer cells.

Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017RNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

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