Paul Bohn's Biography

Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry, University of Notre Dame

Paul W. Bohn received the B.S. from the University of Notre Dame in 1977 and the Ph.D. from the University of Wisconsin-Madison in 1981, both in Chemistry. After two years at Bell Laboratories, he joined the faculty at the University of Illinois at Urbana-Champaign (UIUC). In 2006, he moved to the University of Notre Dame where he is currently the Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering, Professor of Chemistry and Biochemistry, and Director of the Institute for Precision Health. He served as Editor for the Americas for the RSC journal Analyst 2007-09 and as Chair of the Editorial Board 2010-14. Prof. Bohn is currently co-editor of Annual Review of Analytical Chemistry. His research interests include: (a) integrated nanofluidic and microfluidic chemical measurement strategies for personal monitoring, (b) chemical and biochemical sensing in mass-limited samples, (c) biochemical imaging, and (d) molecular approaches to nanotechnology, areas in which he has over 290 publications and 10 patents.

Coupling Photonic and Electrochemical Phenomena with Zero-Dimensional Nanofluidics

Thursday, 5 October 2017 at 14:00

Add to Calendar ▼2017-10-05 14:00:002017-10-05 15:00:00Europe/LondonCoupling Photonic and Electrochemical Phenomena with Zero-Dimensional NanofluidicsRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

The relationship between functional states of redox enzymes and the macroscopically observed phenotype is of fundamental importance to the chemistry of life. However, despite their fundamental importance in basic biochemical phenomena, the direct electrochemical observation of single electron transfer events in biological systems has eluded us until the recent advent of bifunctional nanoelectrochemical-nanophotonic nanopore arrays. High density recessed dual-ring electrode nanopores moderate the interaction between single electron-transfer events and fluorescence emission, in the zeptoliter optical confinement volume of a zero-mode waveguide (ZMW). The dual optical-electrochemical functionality makes it possible to perform single molecule spectroelectrochemical measurements under redox cycling conditions – both when the upper electrode is potential-controlled and using self-induced redox cycling. Single molecule cycling behavior is evidenced in the fluorescence dynamics. Capture efficiencies are characterized as a function of the potential applied to the upper ring electrode, and single molecule electrochemical-spectroscopic cross-correlation measurements are performed as a function of nanopore occupancy down to <n> ~0.001.

Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017RNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

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