Abed Mansour's Biography

Abed Mansour, EMBO Fellow, The Salk Institute

Abed Mansour is currently an EMBO Fellow in the Laboratory of Prof. Fred Gage at the Salk Institute. His research focuses on developing neuronal-3D Organoid platforms derived from human stem cells and harness this technology to study the molecular pathology of neurodegenerative diseases. He received his B.Sc., M.Sc. and PhD in Medical Science and developmental Biology from the Hebrew University of Jerusalem. His graduate studies focused on studying the transcriptional mechanisms that regulate the development of the central nervous system. Following his graduation, Dr. Mansour joined the Weizmann Institute of Science to pursue postdoctoral training on the biology of pluripotent stem cells and cellular reprogramming.

From Brain Organoids to Animal Chimeras: Novel Platforms for Studying Human Brain Development and Disease

Monday, 14 October 2019 at 15:30

Add to Calendar ▼2019-10-14 15:30:002019-10-14 16:30:00Europe/LondonFrom Brain Organoids to Animal Chimeras: Novel Platforms for Studying Human Brain Development and DiseaseStem Cells in Drug Discovery Tox and Organoids 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Due to the immense complexity of the human brain, the study of its development, function, and dysfunction during health and disease has proven to be challenging. The advent of patient-derived human induced pluripotent stem cells, and subsequently their self-organization into three-dimensional brain organoids, which mimics the complexity of the brain's architecture and function, offers an unprecedented opportunity to model human brain development and disease in new ways. However, there is still a pressing need to develop new technologies that recapitulate the long-term developmental trajectories and the complex in vivo cellular environment of the brain. To address this need, we have developed a human brain organoid-based approach to generate a chimeric human/animal brain system that facilitates long-term anatomical integration, differentiation, and vascularization in vivo. We also demonstrated the development of functional neuronal networks within the brain organoid and synaptic-cross interaction between the organoid axonal projections and the host brain. This approach set the stage for investigating human brain development and mental disorders in vivo, and run therapeutic studies under physiological conditions.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonStem Cells in Drug Discovery Tox and Organoids 2019Stem Cells in Drug Discovery Tox and Organoids 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

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