Lorenzo Moroni,
Professor, Biofabrication for Regenerative Medicine,
Maastricht University and Founder MERLN Institute for Technology-Inspired Regenerative Medicine
Prof. Dr. Lorenzo Moroni studied Biomedical Engineering at Polytechnic University of Milan, Italy, and Nanoscale Sciences at Chalmers Technical University, Sweden. He received his Ph.D. cum laude in 2006 at University of Twente on 3D scaffolds for osteochondral regeneration, for which he was awarded the European doctorate award in Biomaterials and Tissue Engineering from the European Society of Biomaterials (ESB). In 2007, he worked at Johns Hopkins University as a post-doctoral fellow in the Elisseeff lab, focusing on hydrogels and stem cells. In 2008, he was appointed the R&D director of the Musculoskeletal Tissue Bank of Rizzoli Orthopedic Institute, where he investigated the use of stem cells from alternative sources for cell banking, and the development of novel bioactive scaffolds for skeletal regeneration. From 2009 till 2014, he joined again University of Twente, where he got tenured in the Tissue Regeneration department. Since 2014 he works at Maastricht University, where he is a founding member of the MERLN Institute for Technology-Inspired Regenerative Medicine. In 2016, he became full professor in biofabrication for regenerative medicine. His research group interests aim at developing biofabrication technologies to generate libraries of 3D scaffolds able to control cell fate, with applications spanning from skeletal to vascular, neural, and organ regeneration. In 2014, he received the prestigious Jean Leray award for outstanding young principal investigators from the ESB and the ERC starting grant. In 2016, he also received the prestigious Young Scientist Award for outstanding principal investigators from TERMIS. In 2017, he was elected as faculty of the Young Academy of Europe and in the top 100 Italian scientists within 40 worldwide by the European Institute of Italian Culture. Since 2019, he is chair of the Complex Tissue Regeneration department and vice-director of MERLN. From his research efforts, 3 products have already reached the market.
3D Scaffolds with Tailorable Topology and Topography through Biofabrication Technologies
Monday, 9 February 2015 at 14:00
Add to Calendar ▼2015-02-09 14:00:002015-02-09 15:00:00Europe/London3D Scaffolds with Tailorable Topology and Topography through Biofabrication TechnologiesSELECTBIOenquiries@selectbiosciences.com
A key factor in scaffold-based tissue and organ regeneration relies on
enhancing (stem) cell-material interactions to obtain the same original
functionality. Different approaches include delivery of biological
factors and surface topography modifications. Although both strategies
have proved to augment cell activity on biomaterials, they are still
characterized by limited control in space and time, which hampers the
proper regeneration of complex tissues. Here, we present a few examples
where the integration of biofabrication technology platforms allowed the
generation of a new library of 3D scaffolds with tailored biological,
physical, and chemical cues at the macro, micro, and nano scale. By
engineering their topological properties, these porous biomaterials
influence the activity of seeded cells, thereby initiating the
regeneration of skeletal, vascular, and neural tissues. Future efforts
should aim at further improving our understanding of scaffold
topological properties to achieve a fine control on cell fate at
multiple scales. This will enable the regeneration of complex tissues
including vasculature and innervation, which will result in enhanced in
vivo integration with surrounding tissues. By doing so, the gap from
tissue to organ regeneration will be reduced, bringing regenerative
medicine technologies closer to the clinics.
Add to Calendar ▼2015-02-09 00:00:002015-02-10 00:00:00Europe/LondonEmerging Themes and Technologies in Tissue Engineering and BioprintingSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-02-09 14:00:002015-02-09 15:00:00Europe/London3D Scaffolds with Tailorable Topology and Topography through Biofabrication TechnologiesSELECTBIOenquiries@selectbiosciences.com
