Jeffrey Morgan,
Professor of Medical Science and Engineering,
Brown University
Jeff Morgan is Professor of Medical Science and Engineering at Brown University. A graduate of Syracuse (BS) and Harvard (PhD) with postdoctoral training at MIT and the Whitehead Institute, he was on the faculty of Harvard Medical School prior to Brown. Dr. Morgan has received numerous awards and patents for his research in gene therapy and tissue engineering and he has co-founded three companies including his latest, Microtissues, Inc (www.microtissues.com). Among his inventions are the 3D Petri Dish®, a technology for growing cells in three dimensions with applications in toxicity testing, drug discovery and tissue engineering. Dr. Morgan has published over 130 peer-reviewed papers, reviews and chapters and has edited two books and is an inventor of 12 U.S. and international patents. He is a Fellow of the National Academy of Inventors as well as a Fellow of the American Institute of Medical and Biological Engineering.
The Bio-Pick, Place and Perfuse: A New Instrument for Layer-by-Layer Building of Tissues and Organs
Tuesday, 10 February 2015 at 11:15
Add to Calendar ▼2015-02-10 11:15:002015-02-10 12:15:00Europe/LondonThe Bio-Pick, Place and Perfuse: A New Instrument for Layer-by-Layer Building of Tissues and OrgansSELECTBIOenquiries@selectbiosciences.com
The grand challenge of the field of tissue engineering is the fabrication of large living structures with high cell density akin to native organs (liver, kidney) and to sustain the viability and functionality of these structures in vitro prior to transplantation. Despite twenty years of engineering different types of scaffolds for cell attachment, this problem remains unsolved and even new efforts to form functional organs by seeding cells into decellularized organs have significant limitations. Rather than pursue a monolithic approach where cells are seeded into a scaffold or decellularized tissue, we are pursuing a bottom up, layer-by-layer and scaffold-free strategy to address some of these engineering problems. When cells are seeded into micro-molds of a nonadhesive hydrogel (agarose) they will aggregate and self-assemble a 3D multi-cellular microtissue. The shape of this microtissue is directed by our design of the micro-mold. We’ve self-assembled large honeycomb shaped tissues. When harvested from the micro-molds, these microtissues will fuse with each other to become one tissue. To build with these microtissue parts, we’ve devised a novel device, the Bio-Pick, Place, and Perfuse (Bio-P3) inspired by the pick & place machines used in the high-speed assembly of multi-component electronics. A significant advance over bio-printing, our first generation device, picks up microtissue building parts, transports them to a build area, and places them at the desired location while maintaining perfusion. In this way, piece by piece, a larger tissue construct can be assembled layer-by-layer, while building and perfusing a vascular-like network that maintains the viability needed for microtissue parts to fuse. This talk will review our progress to date and discuss how this approach may be able to address some of the challenges of organ fabrication.
Add to Calendar ▼2015-02-09 00:00:002015-02-10 00:00:00Europe/LondonEmerging Themes and Technologies in Tissue Engineering and BioprintingSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-02-10 11:15:002015-02-10 12:15:00Europe/LondonThe Bio-Pick, Place and Perfuse: A New Instrument for Layer-by-Layer Building of Tissues and OrgansSELECTBIOenquiries@selectbiosciences.com
