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SELECTBIO Conferences Tissue Engineering

Frederik Claeyssens's Biography

Frederik Claeyssens, Senior Lecturer, Materials Science and Engineering, University of Sheffield

Dr. Frederik Claeyssens is a Senior Lecturer at the Materials Science and Engineering Department at The University of Sheffield (U.K.). During his independent career Dr. Claeyssens established a materials microstructuring laboratory, and his main research explores laser-based 2D and 3D direct-write techniques for (bio)materials micro-structuring and the use of these structures in a range of different applications, e.g. tissue engineering, (bio)sensors, and microelectronics. Frederik Claeyssens has published papers in leading chemistry and materials science journals, he has 82 publications in refereed journals which have received 3059 citations, and an h-index of 27.

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Multi-scale Porosity Biomaterials for Bone-on-a-Chip Devices and Bone Tissue Engineering

Friday, 18 March 2016 at 10:00

Add to Calendar ▼2016-03-18 10:00:002016-03-18 11:00:00Europe/LondonMulti-scale Porosity Biomaterials for Bone-on-a-Chip Devices and Bone Tissue

Natural tissues and organs are typically structured in a hierarchical fashion, in which the Extra-Cellular Matrix (ECM) provides a microporosity to optimally support cell growth while larger scale structures (e.g. vasculature and boundary layers) are incorporated to support the function and structure of the tissue and organ. To mimic this multiscale structuring in synthetic biomaterials we combine additive manufacturing with self-assembly. In this structuring technique the internal porosity is governed by self-assembly and the macroscopic structure is constructed by additive manufacturing. Emulsion templating is used as self-assembly technique to produce materials with a high microscale porosity.  These emulsions can subsequently be used as photocurable resins for stereolithography, producing user-defined macroscale structures with a tissue-like microporosity. The mechanical properties of these materials can be varied via the changing the monomer ratio within the resin. Additionally, biodegradable scaffolds can be fabricated via polycaprolactone-based resins. We produce these hierarchical structured material in 3D structured materials such as woodpile-style scaffolds, microspheres with controllable diameter and as 3D microenvironments that can be integrated in standard poly-dimethylsiloxane (PDMS) based microfluidics. These scaffolds we currently investigate as a platform for bone-on-a-chip based devices and bone tissue engineering.

Add to Calendar ▼2016-03-17 00:00:002016-03-18 00:00:00Europe/LondonTissue