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SELECTBIO Conferences Sample Preparation and Analysis

Barry Lutz's Biography

Barry Lutz, Assistant Professor, University Of Washington

Dr. Lutz received his degrees in Chemical Engineering from the University of Washington and The University of Texas, and he is currently faculty in Bioengineering at the University of Washington. Broadly, his research aims to exploit simple physical and chemical principles to create new biomedical devices, with attention to the clinical needs and technical constraints important to translation. His work has included early contributions to paper-based diagnostics in collaboration with Paul Yager and Elain Fu, and he is Co-Investigator on projects to create next-generation paper-based devices for point-of-care immunoassays (NIH NIAID) and nucleic acid tests (DARPA, Multiplexable Autonomous Disposable Nucleic Acid Amplification Test – MAD NAAT). His new lab at the University of Washington is turning attention to sophisticated nucleic acid analyses including high-order multiplexed diagnostic test panels, mutation detection, drug resistance, and sequence-based diagnostic analyses. These methods are normally associated with the most sophisticated laboratories; we aim to re-engineer their chemistries to be fast, simple, and robust with a goal to create on-site rapid turn-around tests with high information content for clinical diagnostics.

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Sample-to-Result Molecular Diagnostics in an Easy-to-Use Disposable Test

Tuesday, 24 March 2015 at 14:00

Add to Calendar ▼2015-03-24 14:00:002015-03-24 15:00:00Europe/LondonSample-to-Result Molecular Diagnostics in an Easy-to-Use Disposable

Infectious diseases are a leading cause of death in the developing world.  Even when treatment is available, misdiagnosis leads to ineffective treatment, waste of scarce medications, and increased pressure for drug resistance. While these diseases can be diagnosed in centralized laboratories, these assays require trained operators to carry out multi-step assay protocols, expensive and fragile instrumentation, and cold storage conditions for many reagents. At the University of Washington we are developing rapid immunoassays and nucleic acid tests designed for minimal-resource settings, whether it be a pharmacy, an outdoor clinic, or your home. DARPA is supporting a project to develop a fully-disposable test for multiplexed detection of DNA and RNA that is simple enough for home use. All steps from sample preparation to visual readout are carried out automatically, and there is no need for external equipment or sample handling by the user (other than swabbing their nose). Data collection by a cell phone could allow transmission of results to a healthcare provider and medical record. Project goals include commercializable tests as well as broad platform capabilities for future tests. I will present the concept and progress as a means for sample-to-result testing outside conventional labs, and perhaps even in your home.

Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonSample Preparation and