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SELECTBIO Conferences Circulating Biomarkers 2014

Maiwenn Kersaudy-Kerhoas's Biography

Maiwenn Kersaudy-Kerhoas, Associate Professor, School of Engineering and Physical Sciences, Heriot-Watt University

Dr Maiwenn Kersaudy-Kerhoas is a Royal Academy of Engineering Research Fellow, Assistant Professor at Heriot-Watt University and Honorary Fellow at the University of Edinburgh. She received her PhD in the area of Microengineering at Heriot-Watt University, Edinburgh. In 2015, she joined the division of Infection and Pathway Medicine, at the College of Medicine, University of Edinburgh where her research group is currently based. Since 2016 she is a member of the Royal Society of Edinburgh Young Academy of Scotland.

Maiwenn Kersaudy-Kerhoas Image

Enrichment of Fetal DNA Fractions by Microfluidic Extraction of Maternal Plasma

Tuesday, 25 March 2014 at 15:30

Add to Calendar ▼2014-03-25 15:30:002014-03-25 16:30:00Europe/LondonEnrichment of Fetal DNA Fractions by Microfluidic Extraction of Maternal PlasmaCirculating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,

The presence of circulating fetal nucleic acids in maternal circulation provides a unique opportunity for Non Invasive Prenatal Testing (NIPT) as an alternative to invasive techniques such as amniocentesis or chorionic villus sampling. Prompt and effective enrichment of circulating fetal DNA from blood impact the ability to perform testing. We propose a microfluidic device to rapidly enrich fetal DNA from 2-4mL maternal blood samples. We will show that in plasma extracted on-chip a three-fold average relative amount of fetal DNA (compared with total DNA) was obtained compared to plasma extracted via centrifugation (p=0.02). We therefore demonstrate that a portable microfluidic device can significantly enriches fetal fractions from maternal blood samples in one single step. The operation requires minimal training and does not need large items of specialized equipment. This device may be deployed near-patient to improve the testing accuracy and ability to test NIPT samples with low fetal fractions.

Add to Calendar ▼2014-03-24 00:00:002014-03-25 00:00:00Europe/LondonCirculating Biomarkers 2014Circulating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,