Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Circulating Biomarkers 2014

Maiwenn Kersaudy-Kerhoas's Biography

Maiwenn Kersaudy-Kerhoas, Associate Professor, School of Engineering and Physical Sciences, Heriot-Watt University

Dr Kersaudy-Kerhoas’ research has focused on the development of microfluidic tools for the preparation of human blood samples prior to analytical detection of biomarkers such as DNA, RNA and microRNA. This involves the design of hydrodynamic plasma separation features and the integration of nucleic acid extraction into microfluidic workflows. She works closely with biologists and clinicians to develop applications in the field of non-invasive prenatal testing, cancer and beyond.

Her interests in Manufacturing Research lie in micro and nanotechnologies, rapid prototyping and the development of cost-effective manufacturing processes for medium to high volume production of polymeric microfluidic components. She is also interested in the replacement of petroleum-derived products by composites derived from renewable resources in the production of high-value microsystems.

In 2017, she won the £1.3M UK Engineering and Physical Sciences Research Council Healthcare Technology Challenge Award (2018-2022).

Maiwenn Kersaudy-Kerhoas Image

Enrichment of Fetal DNA Fractions by Microfluidic Extraction of Maternal Plasma

Tuesday, 25 March 2014 at 15:30

Add to Calendar ▼2014-03-25 15:30:002014-03-25 16:30:00Europe/LondonEnrichment of Fetal DNA Fractions by Microfluidic Extraction of Maternal PlasmaCirculating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,

The presence of circulating fetal nucleic acids in maternal circulation provides a unique opportunity for Non Invasive Prenatal Testing (NIPT) as an alternative to invasive techniques such as amniocentesis or chorionic villus sampling. Prompt and effective enrichment of circulating fetal DNA from blood impact the ability to perform testing. We propose a microfluidic device to rapidly enrich fetal DNA from 2-4mL maternal blood samples. We will show that in plasma extracted on-chip a three-fold average relative amount of fetal DNA (compared with total DNA) was obtained compared to plasma extracted via centrifugation (p=0.02). We therefore demonstrate that a portable microfluidic device can significantly enriches fetal fractions from maternal blood samples in one single step. The operation requires minimal training and does not need large items of specialized equipment. This device may be deployed near-patient to improve the testing accuracy and ability to test NIPT samples with low fetal fractions.

Add to Calendar ▼2014-03-24 00:00:002014-03-25 00:00:00Europe/LondonCirculating Biomarkers 2014Circulating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,