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SELECTBIO Conferences Circulating Biomarkers 2014

Maiwenn Kersaudy-Kerhoas's Biography

Maiwenn Kersaudy-Kerhoas, Professor of Microfluidic Engineering, Heriot-Watt University

Maïwenn Kersaudy-Kerhoas is a Professor of Microfluidic Engineering at Heriot-Watt University in Edinburgh, Scotland. She leads a multi-disciplinary research group of biologists and engineers. Her work has focused on the development of robust, reproducible and affordable prototyping methods for point-of-care diagnostics. She has developed several pre-analytical tools for liquid biopsies applications with clinicians, including blood plasma separation devices, cell-free DNA extraction cartridges and a finger-actuated blood processing device. In 2013, she received a five year Royal Academy of Engineering Fellowship and in 2018 a Healthcare Technology Challenge Award from the UK Engineering and Physical Science Council. In 2019 she was awarded a Royal Academy of Engineering ‘Frontiers of Development’ and Global Challenge Research Fund seed funding to develop an advanced sepsis diagnostic tool via cell-free microbial nucleic sequencing with clinical partners around the world. She is a recipient of the 2023 Royal Academy of Engineering Frontiers Champion award, which she will use for the creation of a Frugal Diagnostic network.

Maiwenn Kersaudy-Kerhoas Image

Enrichment of Fetal DNA Fractions by Microfluidic Extraction of Maternal Plasma

Tuesday, 25 March 2014 at 15:30

Add to Calendar ▼2014-03-25 15:30:002014-03-25 16:30:00Europe/LondonEnrichment of Fetal DNA Fractions by Microfluidic Extraction of Maternal PlasmaCirculating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,

The presence of circulating fetal nucleic acids in maternal circulation provides a unique opportunity for Non Invasive Prenatal Testing (NIPT) as an alternative to invasive techniques such as amniocentesis or chorionic villus sampling. Prompt and effective enrichment of circulating fetal DNA from blood impact the ability to perform testing. We propose a microfluidic device to rapidly enrich fetal DNA from 2-4mL maternal blood samples. We will show that in plasma extracted on-chip a three-fold average relative amount of fetal DNA (compared with total DNA) was obtained compared to plasma extracted via centrifugation (p=0.02). We therefore demonstrate that a portable microfluidic device can significantly enriches fetal fractions from maternal blood samples in one single step. The operation requires minimal training and does not need large items of specialized equipment. This device may be deployed near-patient to improve the testing accuracy and ability to test NIPT samples with low fetal fractions.

Add to Calendar ▼2014-03-24 00:00:002014-03-25 00:00:00Europe/LondonCirculating Biomarkers 2014Circulating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,