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SELECTBIO Conferences Extracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics

Dolores Di Vizio's Biography

Dolores Di Vizio, Professor, Cedars Sinai Medical Center

Dr. Dolores Di Vizio is a pathologist and a molecular and cell biologist trained at Albert Einstein College of Medicine, and Harvard Medical School. Dr. Di Vizio holds an academic appointment as associate professor at Cedars-Sinai Medical Center, and at the University of California, Los Angeles. She is an Executive Chair of the International Society of Extracellular Vesicles (ISEV). Her group studies the molecular mechanisms of progression to advanced disease in human tumors, with a particular emphasis on large oncosomes, extracellular vesicles (EVs) shed into the extracellular space from fast migrating and metastatic amoeboid cancer cells. Her lab is currently profiling the large oncosomes and other EV populations by NGS and proteomics for functional and molecular characterization.

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Extracellular Vesicle-Derived Analytes for Cancer Progression

Thursday, 25 February 2021 at 11:30

Add to Calendar ▼2021-02-25 11:30:002021-02-25 12:30:00Europe/LondonExtracellular Vesicle-Derived Analytes for Cancer ProgressionExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics in Virtual ConferenceVirtual

Cancer-derived extracellular vesicles (EVs) are highly heterogenous and include atypically large particles (1-10 microns), known as large oncosomes that are abundant in PC patients with metastatic PC and are enriched with tumor-derived cargo. Next Generation Sequencing studies (whole genome and whole transcriptome) as well as Mass Spectrometry studies using different approaches, including SILAC, have enabled us to refine the methodologies that allow to isolate and characterize these vesicles in human plasma samples from patients with prostate cancer with high rigor and reproducibility.  We are building upon our studies and moving forward with a deep characterization of the protein content of large oncosomes and the development of a preclinical platform that can help translating our laboratory investigations to the clinic.  One of our long term goals is to undertake an integrative approach that takes advantage of all the macromolecules carried in these tumor-derived particles and ultimately identify epigenomic, metabolic, transcriptional and other functional pathways that can be extracted from plasma vesicles and provide tumor information in real time.

Add to Calendar ▼2021-02-25 00:00:002021-02-26 00:00:00Europe/LondonExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and TherapeuticsExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics in Virtual ConferenceVirtual