Héctor Peinado Selgas,
Head of Microenvironment and Metastasis Group,
Spanish National Cancer Research Centre (CNIO), Weill Medical College of Cornell University
I did my PhD in the laboratory of Dr. Amparo Cano in Madrid (Spain, Biomedical Research Institute “Alberto Sols”) where I specialized in analyzing Epithelial to Mesenchymal Transition Mechanisms. In this lab we described the molecular mechanisms of EMT regulated by Snail transcription factor and Lysyl Oxidase 2 (EMBO J (2005) 24:3446-58, Nat. Rev Cancer. (2007). 7:415-28). I defined a role for beta-catenin in regulating cancer stem cell behavior in skin cancer (Nature. (2008) 452:650-3). I joined Dr. Lyden’s laboratory as a postdoctoral associate in 2008 to study the crosstalk between tumor cells and bone marrow derived cells during metastatic progression. During these years I developed my career as an independent researcher with an excellent collaboration with Dr. Lyden. In 2010, was appointed to a Faculty Position in the Department of Pediatrics at WCMC and in 2013 I was promoted to Assistant Professor. My work has recently defined that tumor-secreted exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype (Nature Medicine. 2012. (18): 883-891.). My current research goals are focused on understanding the crosstalk between the tumor and its microenvironment by exosomes and the development of new diagnostic test to monitor response to therapy.
Defining the Role of Tumor-secreted Exosomes in Metastasis and as Surrogate Markers of DNA Mutations
Tuesday, 24 March 2015 at 13:30
Add to Calendar ▼2015-03-24 13:30:002015-03-24 14:30:00Europe/LondonDefining the Role of Tumor-secreted Exosomes in Metastasis and as Surrogate Markers of DNA MutationsSELECTBIOenquiries@selectbiosciences.com
Cancer is a systemic disease, while most of the research effort has been focused on analyzing the primary tumor, there is a lack of information on how the tumor microenvironment influences metastasis and metastatic niche formation. The importance of the microenvironment in cancer formation, metastasis and treatment is now fully acknowledged. Prominent roles for resident cells, such as fibroblasts, bone marrow-derived cells, soluble factors, ECM molecules and secreted vesicles have been established. We have recently found a novel role for tumor-secreted exosomes promoting a pro-metastatic phenotype of bone marrow progenitor cells through in a process called ‘education of the tumor microenvironment’. In addition, in collaboration with Drs. David Lyden and Jacqueline Bromberg, we have found that double stranded DNA is secreted in tumor exosomes and reflects the mutational status of parental tumor cells. The analysis of cargo and DNA in plasma-circulating exosomes in cancer patients demonstrated that they contain specific signatures and mutations being critical factors in diagnosis and prognosis. Our studies suggest that specific molecules shed on tumor exosomes dictate the behavior of the tumor microenvironment favoring metastasis.
Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonExosomes and MicrovesiclesSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2015-03-24 13:30:002015-03-24 14:30:00Europe/LondonDefining the Role of Tumor-secreted Exosomes in Metastasis and as Surrogate Markers of DNA MutationsSELECTBIOenquiries@selectbiosciences.com
