Geraldine A Hamilton,
President/Chief Scientific Officer,
Dr. Hamilton's career spans academic research, large Pharma, and biotech start-ups, with over 10 years’ experience in the pharmaceutical industry. In all three arenas, Dr. Hamilton's work has focused on the development of new human-relevant cell-based models and their application to drug discovery. This pursuit brought Dr. Hamilton to Harvard's Wyss Institute, where as a Lead Senior Staff Scientist she directed the extensive Organs-on-Chips project. This project was successfully spun-out from the Wyss Institute to form Emulate, Inc., where Dr. Hamilton now serves as President and Chief Scientific Officer. At Emulate, Dr. Hamilton continues her work to further develop Organs-on-Chips technology as well as to drive and facilitate its adoption in commercial use. Prior to joining the Wyss Institute and Emulate, Dr. Hamilton was one of the founding scientists of the biotech start-up CellzDirect, where she was the VP of Scientific Operations and Director of Cell Products. CellzDirect successfully translated and commercialized technology from academic research to supply the pharmaceutical industry with hepatic cell products and services for safety assessment and drug-metabolism studies. Hamilton received her Ph.D. in cell biology/toxicology from the University of Hertfordshire (England) in conjunction with GlaxoSmithKline, followed by a post-doctoral research fellowship at the University of North Carolina. She has led in vitro toxicology and drug metabolism teams in GlaxoSmithKline and AstraZeneca. Her current research interests and scientific experience include: bioinspired engineering, toxicology and drug metabolism, liver cell biology, mechanisms regulating gene expression and differentiation, regulation of nuclear receptors and transcriptional activation in hepatocytes by xenobiotics, human cell isolation and cryopreservation techniques.
Organs-on-Chips: Predicting Human Physiology and Pathobiology
Tuesday, 10 February 2015 at 09:30
Add to Calendar ▼2015-02-10 09:30:002015-02-10 10:30:00Europe/LondonOrgans-on-Chips: Highly Functional Microphysiological Systems to Predict Human Physiology and PathobiologyTissue Engineering and Bioprinting: Research to Commercialization in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
This presentation will review our novel biomimetic microsystem technologies and discuss their potential application in predicting efficacy, safety and mechanism of action for new drugs, chemicals, and cosmetics. Biomimetic Organs-on-Chips offer exciting new approaches to attack fundamental questions in biology, and develop smart in vitro surrogates for regulatory sciences that can positively impact human health. We apply microfabrication approaches to engineer cell culture microenvironments that go beyond conventional three-dimensional cell culture models by recapitulating the tissue-tissue interfaces, spatiotemporal chemical gradients, mechanical microenvironments, and physiological function of living organs. These Organs-on-Chips are being combined with cultured human cells to study human physiology in an organ-specific context. The presentation will also highlight the potential application of these systems for disease model development, standing as more predictive, human-relevant alternatives to current animal-based models.
Add to Calendar ▼2015-02-09 00:00:002015-02-10 00:00:00Europe/LondonTissue Engineering and Bioprinting: Research to CommercializationTissue Engineering and Bioprinting: Research to Commercialization in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com