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SELECTBIO Conferences Sample Preparation and Analysis

Daniel Irimia's Biography

Daniel Irimia, Associate Professor, Surgery Department, Massachusetts General Hospital (MGH), Shriners Burns Hospital, and Harvard Medical School

Daniel Irimia was trained as a medical doctor and a bioengineer. He is leading a research team that designs microfluidic devices for biomedical applications. He published more than 150 articles on multidisciplinary studies involving microfluidics, inflammation, infections, and sepsis.

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Breakfast Briefing: Measuring Neutrophil Phenotype in Sepsis from a Single Drop of Blood

Tuesday, 24 March 2015 at 08:00

Add to Calendar ▼2015-03-24 08:00:002015-03-24 09:00:00Europe/LondonBreakfast Briefing: Measuring Neutrophil Phenotype in Sepsis from a Single Drop of

The absolute neutrophil count (ANC) is today one of the most common blood tests used in the clinic for evaluating the risk of infections in patients.  However, this test implicitly assumes that all patients’ neutrophils are normal and it does not account for possible alterations of their functions.  Such alterations occur in patients after burn injury and can significantly reduce the ability of the body to fight infections, even when neutrophils counts are in the normal range.  To estimate the risk for infections more accurately, we designed microfluidic devices that measure neutrophil migration with higher precision than ever before.  To circumvent the challenging logistics of neutrophil isolation in the clinic, we designed these devices to work directly with one droplet of blood.  Using these devices, we identified a set of phenotype markers for the early detection and monitoring of sepsis in patients after major burn injuries.

Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonSample Preparation and