| Conferences \ Cancer Immunotherapy & Biofluid Biopsies 2016 \ Agenda \ Francesco Marangoni |
| Register | Login |
The Generation of Tumor-Associated T Regulatory Cells Critically Depends on CalcineurinWednesday, 2 November 2016 at 16:00  Add to Calendar ▼2016-11-02 16:00:002016-11-02 17:00:00Europe/LondonThe Generation of Tumor-Associated T Regulatory Cells Critically Depends on CalcineurinCancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.comCD4+FoxP3+ T regulatory cells (Tregs)
play a key role maintaining immune homeostasis, yet they are also
improperly co-opted by tumors where they blunt anti-tumor immunity and
facilitate progression. Treg function is maintained in vivo by
continuous triggering of the T cell receptor (TCR), yet it is unknown
how interactions between Tregs and APCs in the context of
tumor development dynamically trigger the TCR and the numerous signaling
pathways downstream of it. Among these, the role of the calcineurin /
NFAT pathway in Treg biology is controversial. We thus investigated the role of calcineurin / NFAT signaling in supporting tumor-associated Treg (TuTreg)
generation and function by using mice with Treg-specific deletion of
calcineurin B (CnB) and intravital imaging of NFAT activation. |
Add to Calendar ▼2016-11-01 00:00:002016-11-02 00:00:00Europe/LondonCancer Immunotherapy and Biofluid Biopsies 2016Cancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
