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SELECTBIO Conferences Exosomes and Microvesicles:  Research, Biomarker Cargo and Therapeutic Potential

Shannon Pendergrast's Biography

Shannon Pendergrast, Chief Scientific Officer, Ymir Genomics

Dr. Pendergrast received his PhD from the Rutgers University Waksman Institute of Microbiology in Molecular Genetics, did his post-doctoral training at Cold Spring Harbor Laboratories, and has over 12 years of experience in industry as a Scientist, Executive, and Entrepreneur. Throughout his career Dr. Pendergrast has developed cutting edge methods to further our understanding of biological processes. As a graduate fellow in the lab of Dr. Richard Ebright a post-doctoral research with Dr. Nouria Hernandez and a Senior Principal Investigator at The Archemix Corp he developed a new methods to characterize protein-nucleic acid complexes for research and drug discovery. As CSO of Ymir Genomics LLC he entered the field of Biomarker Discovery and characteristically went right to work developing innovative new methods to improve extracellular biomarker isolation from biofluids. He has published over 30 scientific papers, patents and book chapters and is an Associate Editor of the Journal of Circulating Biomarkers.

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Enabling Urine Biomarker Discovery

Monday, 21 March 2016 at 17:00

Add to Calendar ▼2016-03-21 17:00:002016-03-21 18:00:00Europe/LondonEnabling Urine Biomarker

The discovery of urinary extra-cellular biomarkers has been impeded by the lack of efficient methods for the isolation of extra-cellular vesicles (exosomes and microvesicles), protein, and nucleic acid.  Ultracentrifugation, considered the gold standard for vesicle isolation from many biofluids, is efficacious but laborious, and like most commercially available methods, is unable to consistently isolate enough quality material from small volumes of urine for protein or RNA-based biomarker discovery.  Ymir Genomics has invented a novel precipitation reagent that rapidly and efficiently isolates extra-cellular biomolecules and vesicles from urine samples yielding a quantity suitable for biomarker discovery.  Ymirite is more efficient than either ultracentrifugation or commercial precipitation methods for isolating extra-cellular nucleic acids and vesicles from a variety of urine samples as evaluated by immunoblot, Nanosight, Electron Microscopy, miRNA microarray, and qRT-PCR. Moreover, unlike all other methods, our reagent was able to isolate vesicles from very dilute samples. Ymir Genomic’s Precipitation Reagent offers a method that, in less than 30 minutes, isolates intact extra-cellular vesicles, protein and RNA suitable for biomarker discovery from urine samples.

Add to Calendar ▼2016-03-21 00:00:002016-03-22 00:00:00Europe/LondonExosomes and Microvesicles: Research, Biomarker Cargo and Therapeutic