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SELECTBIO Conferences 3D-Culture, Organoids and Organs-on-Chips 2021

Roger Kamm's Biography

Roger Kamm, Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, Massachusetts Institute of Technology (MIT)

Kamm is currently the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering at MIT, where he has served on the faculty since 1978. Kamm has long been instrumental in developing research activities at the interface of biology and mechanics, formerly in cell and molecular mechanics, and now in engineered living systems. Current interests are in developing models of healthy and diseased organ function using microfluidic technologies, with a focus on vascularization. Kamm has fostered biomechanics as Chair of the US National Committee on Biomechanics (2006-2009) and of the World Council on Biomechanics (2006-2010). Kamm currently directs the NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems. He is the 2010 recipient of the ASME Lissner Medal (American Society of Mechanical Engineering) and the 2015 recipient of the Huiskes Medal (European Society of Biomechanics), both for lifetime achievements, and is the inaugural recipient of the ASME Nerem Medal for mentoring and education. He was elected to the National Academy of Medicine in 2010. Kamm is co-founder of two companies, Cardiovascular Technologies and AIM Biotech, a manufacturer of microfluidic systems for 3D culture.

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Strategies For in vitro Perfusion of iPSC-derived Organoids: A Tough Nut to Crack

Monday, 22 March 2021 at 09:00

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Now that organoids can be generated for a variety of organs and tissues from induced pluripotent stem cells, there is tremendous interest in developing methods to connect an external perfusion system to an internal vasculature.  Success in this quest would help facilitate continuous perfusion, leading to improved viability and functionality of the developing organ, and supporting the introduction of therapeutics for drug screening and development.  For more than 5 years, we have had the capability to grow self-assembled microvascular beds, or pattern small vessels within various hydrogels.  Methods are also increasingly available to induce the growth vascular networks inside of the organoid. To date, however, it has proved challenging to induce anastomosis between these two networks and enable continuous perfusion. In this presentation, different methods will be discussed that hold promise to address this critical problem.

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