Yanyi Huang's Biography

Yanyi Huang, Professor, Peking University

Dr. Yanyi Huang received his BS (Chemistry) and ScD (Inorganic Chemistry) degrees from Peking University in 1997 and 2002, respectively. He then conducted his postdoc research at Caltech (Applied Physics, 2002-2005) and Stanford (Bioengineering, 2005-2006). He started his independent career at Peking University in 2006 as a Principal Investigator and was promoted to Associate Professor in 2009, and Professor in 2013. He is Professor of Materials Science and Engineering, Principal Investigator in Biomedical Pioneering Innovation Center (BIOPIC), Principal Investigator in Beijing Advanced Innovation Center for Genomics (ICG), Principal Investigator in Peking-Tsinghua Center for Life Sciences, and an Adjunct Professor of Analytical Chemistry.

High Throughput Error-Correction Code DNA Sequencing

Thursday, 14 November 2019 at 15:30

Add to Calendar ▼2019-11-14 15:30:002019-11-14 16:30:00Europe/LondonHigh Throughput Error-Correction Code DNA SequencingMicrofluidics and Organ-on-a-Chip Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com

Eliminating errors in next-generation DNA sequencing has proved challenging. I am going to talk about our newly developed error-correction code (ECC) sequencing, a method to greatly improve sequencing accuracy by combining fluorogenic sequencing-by-synthesis (SBS) with an information theory–based error-correction algorithm. ECC embeds redundancy in sequencing reads by creating three orthogonal degenerate sequences, generated by alternate dual-base reactions. This is similar to encoding and decoding strategies that have proved effective in detecting and correcting errors in information communication and storage. We showed that, when combined with a fluorogenic SBS chemistry with raw accuracy of 98.1%, ECC sequencing provides single-end, error-free sequences up to 200 bp. ECC approaches should enable accurate identification of extremely rare genomic variations in various applications in biology and medicine.

Add to Calendar ▼2019-11-14 00:00:002019-11-15 00:00:00Europe/LondonMicrofluidics and Organ-on-a-Chip Asia 2019Microfluidics and Organ-on-a-Chip Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com

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