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SELECTBIO Conferences Microfluidics & Organ-on-a-Chip Asia 2019

Microfluidics & Organ-on-a-Chip Asia 2019 Agenda


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Thursday, 14 November 2019

00:00

Reverse Bioengineering of Living Systems For Drug Discovery
Ken-ichiro Kamei, Associate Professor, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan

One of the ultimate goals of bioengineering is to re-create natural living systems by means of synthetic biology and tissue engineering. The long-term mission of our laboratory is to recapitulate the in vivo physiology and pathology on a microfluidic device, such as “Body-on-a-Chip” (BoC) or “Microphysiological Systems” (MPSs). Indeed, OOC/MPSs exhibit great potential as alternatives for pre-clinical animal tests to assess drug efficacy and safety. Although several chips and systems have been reported in the last decade, there are still some important issues that need to be addressed; these include: 1) the use of functional tissue cells derived from human pluripotent stem cell (hPSC), 2) the alternatives of polydimethylsiloxane (PDMS) to prevent chemical absorption, and 3) the integration of in situ monitoring systems to monitor cellular responses. Here, our interdisciplinary approach of stem cell biology, material science, and micro/nano-engineering will be introduced to address the aforementioned issues involved in drug discovery and precision medicine.

00:00

Engineering of a Vascularized 3D Cell Construct On-Chip Using Human iPSC-derived Cells
Yu-suke Torisawa, Associate Professor, Hakubi Center for Advanced Research, Kyoto University, Japan

Vascular networks are essential to maintain cellular viability and function; however, current 3D culture models lack vascular systems.  Engineering perfusable vascular networks that can deliver reagents and blood cells to 3D cell constructs could be a powerful platform to recapitulate cellular microenvironments and tissue-level functions.  We have developed a microfluidic method to form vascularized tissue-like cell constructs to model cellular interactions through blood vessels.  When a tumor-like cell spheroid containing human umbilical vein endothelial cells (HUVECs) and fibroblasts was cultured in our microfluidic device, a perfusable vascular network was formed through the cancer spheroid.  We confirmed that peripheral blood mononuclear cells can be perfused inside a cancer spheroid through a vascular network.  Thus, we used this system to model the interaction between cancer cells and immune cells.  To study the interaction between cytotoxic T cells and cancer cells thorough blood vessels, allo-reaction between endothelial cells and T cells by mismatching of their HLA will be problematic.  Therefore, we engineered 3D vascular networks using human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs).  CD8+ T cells primed by HUVECs exhibited higher cytotoxic activity toward HUVECs than autologous hiPSC-ECs and MHC class I KO-hiPSC-ECs, demonstrating the potential value of this vascularized cancer-on-a-chip for modeling the interaction between T cells and a tumor-like tissue through blood vessels.  Generation of in vivo-like vascularized 3D cell constructs using hiPSC-ECs would provide a novel platform to develop organs-on-chips as well as human disease models.

00:00

Vascularized Tissue Engineering
Tatsuya Shimizu, Director and Professor, Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Japan

Most tissues and organs need perfusable micro blood vessels.  We have succeeded in introduction of micro blood vessels in three-dimensional functional tissues.  Recent advances in vascularized tissue engineering will be presented and discussed.

00:00

Title to be Confirmed.
Kennedy Okeyo, Senior Lecturer, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan

00:00

Keisuke GodaConference Chair

Title to be Confirmed.
Keisuke Goda, ImPACT Program Manager, Japan Science and Technology Agency, Professor of Physical Chemistry, University of Tokyo, Japan

00:00

Title to be Confirmed.
Y. Shrike Zhang, Assistant Professor of Medicine, Harvard Medical School, Associate Bioengineer, Division of Engineering in Medicine, Brigham and Women’s Hospital, United States of America

00:00

Dan HuhKeynote Presentation

Title to be Confirmed.
Dan Huh, Assistant Professor and Wilf Family Term Endowed Chair, University of Pennsylvania, United States of America

00:00

Martyn BoutelleKeynote Presentation

Title to be Confirmed.
Martyn Boutelle, Professor of Biomedical Sensors Engineering, Vice Chair Department of Bioengineering, Imperial College London, United Kingdom

00:00

High-Throughput Raman Flow Cytometry
Kotaro Hiramatsu, Assistant Professor, The University of Tokyo, Japan

I present the development of a high-throughput (>2,000 cells/s) and broadband (400-1600 cm-1) Raman spectroscopic flow cytometry and its application to large-scale single-cell analyses of the astaxanthin productivity and photosynthetic dynamics of Haematococcus lacustris.

00:00

Modulation of Molecular Signaling in Single Cells By Femtosecond Laser
Hao He, Professor, Shanghai Jiao Tong University, China

Our recent progresses on direct control of cellular Ca2+ channels and Ca2+ signaling by femtosecond laser in single cells without optogenetics will be introduced. We developed all-optical methods to control cellular molecules on a cover slide.

00:00

An-Bang WangKeynote Presentation

Promoting Microfluidics From the Lab to Real Biomedical Applications
An-Bang Wang, Professor, Institute of Applied Mechanics, National Taiwan University, Taiwan

Microfluidics could bring significant advantages in the applications of chemical reaction, process control and bio-medical detection. In the past seventeen years, the research topics have been shifted from different microfluidic components in our lab, including micropump, microvalve, and micromixer etc., to various integration systems, e.g., micro-multiphase flow/multiemulsion generators, microreactor, high-throughput fluid/flow properties detection, and the maskless pattern coating technology by two-phase microfluidic method, etc. Recently, special efforts were made for the extension of the microfluidic applications in the life science studies and clinical diagnoses with advantages of easy use, compact size and excellent cost performance, e.g., a lab-on-a-chip with sequential control for biomedical point-of-care testing and a new extremely material- and time-saving Western blotting method that is widely used in analytical chemistry.

00:00

Dino Di CarloKeynote Presentation

Title to be Confirmed.
Dino Di Carlo, Professor and Vice Chair of Bioengineering, University of California-Los Angeles, United States of America

00:00

Title to be Confirmed.
Hiroshi Kimura, Associate Professor, Dept of Mechanical Engineering, Tokai University, Japan


Agenda is not currently available
Add to Calendar ▼2019-11-14 00:00:002019-11-15 00:00:00Europe/LondonMicrofluidics and Organ-on-a-Chip Asia 2019Microfluidics and Organ-on-a-Chip Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com