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SELECTBIO Conferences RNAi and miRNA

Jiri Vanicek's Biography



Jiri Vanicek, Assistant Professor, EFPL

Jiri Vanicek earned both his bachelor's degree and doctorate in theoretical physics at Harvard. From 2003 to 2005, he held postdoctoral positions at the Mathematical Sciences Research Institute and the Department of Chemistry of the University of California in Berkeley. From 2005 to 2007, as a fellow at the Simons Center for Systems Biology at the Institute for Advanced Study in Princeton, Jiri Vanicek applied methods of statistical physics to predict microRNA targets in herpesviruses. In 2007 he joined the faculty of École Polytechnique Fédérale de Lausanne, where his research focuses on developing algorithms for quantum molecular dynamics, predicting microRNA targets, and understanding microRNA biology in general.

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Analysis of the Accessibility of PAR-CLIP Bound Sites Reveals that Nucleation of the miRNA:mRNA Pairing Occurs Preferentially at the 3'-end of the Seed Match

Tuesday, 4 September 2012 at 16:30

Add to Calendar ▼2012-09-04 16:30:002012-09-04 17:30:00Europe/LondonAnalysis of the Accessibility of PAR-CLIP Bound Sites Reveals that Nucleation of the miRNA:mRNA Pairing Occurs Preferentially at the 3'-end of the Seed MatchSELECTBIOenquiries@selectbiosciences.com

Detailed analysis of PAR-CLIP miRNA binding sites demonstrates that miRNA target binding starts preferentially at the 3' end of the seed match. Complementary analysis of mRNA and protein levels shows that genes with accessible nucleation regions at the 3'-end are more strongly downregulated than other genes.


Add to Calendar ▼2012-09-04 00:00:002012-09-05 00:00:00Europe/LondonRNAi and miRNASELECTBIOenquiries@selectbiosciences.com