Welcome to the ISEV2014 Education Event by the President of ISEVSunday, 26 October 2014 at 10:00  Add to Calendar ▼2014-10-26 13:00:002014-10-26 14:00:00Europe/LondonThe Diversity of Extracellular Vesicles and Their RNA CargoISEV2014 Educational Event in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.comThe President of ISEV will provide an introduction to the International Society for Extracellular Vesicles (ISEV) and will describe the goals and objectives of ISEV.
Extracellular Vesicle Round-Table Discussions with BeerSunday, 26 October 2014 at 18:45 Add to Calendar ▼2014-10-26 13:00:002014-10-26 14:00:00Europe/LondonThe Diversity of Extracellular Vesicles and Their RNA CargoISEV2014 Educational Event in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.comAll Speakers and Conference Delegates are Invited to the Round-Table Discussions at the Conclusion of the Conference Presentations.
The Diversity of Extracellular Vesicles and Their RNA CargoSunday, 26 October 2014 at 13:00 Add to Calendar ▼2014-10-26 13:00:002014-10-26 14:00:00Europe/LondonThe Diversity of Extracellular Vesicles and Their RNA CargoISEV2014 Educational Event in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.comMost cells have the capacity to release different types of extracellular vesicles, which typically have an intact cell membrane which protects the cytoplasmic vesicular cargo. These extracellular vesicles include exosomes, microvesicles as well as apoptotic bodies, where the exosomes are the truly nano-sized vesicles, with a diameter range of 40-100 nm. In 2007, we were first to show that exosomes released from mast cells contain both microRNA and mRNA, which subsequently can be transferred from one cell to another, and mediate functionality. Importantly, the RNA cargo in exosomes are not directly related to the exosome-producing cell RNA, suggesting that specific mechanisms are involved in packaging RNA into exosomes. Subsequently, it has been shown that exosomes in all human body fluids investigated do contain RNA, including serum, plasma, saliva, semen and breast milk. Importantly, the RNA content in exosomes changes when the cells undergo for example oxidative stress. The capacity of exosomes to shuttle RNA between cells, has of course increased the complexity by which cells communicate with each other. Thus, this level of communication is significantly different from the classical communication pathways, including protein-receptor interaction as well as neural transmission. Importantly, different extracellular vesicles contain different RNA species, as well documented in different studies using different models. Therefore, cells may mediate multiple RNA-mediated signals by shuttling also other extracellular vesicles than exosomes to other cells. This presentation will primarily discuss the different RNA cargo in subsets of extracellular vesicles, including apoptotic bodies, microvesicles and exosomes, but also in relation to subgroups of vesicles within the exosomes population, and relate the studies to putatively clinically important effects of the vesicles. |
Add to Calendar ▼2014-10-26 00:00:002014-10-26 00:00:00Europe/LondonISEV2014 Educational EventISEV2014 Educational Event in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
