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SELECTBIO Conferences Circulating Biomarkers 2014

Xandra Breakefield's Biography

Xandra Breakefield, Professor, Mass General Hospital (MGH)/Harvard Medical School

Xandra Breakefield, Ph.D. is a basic scientist with a strong background in molecular genetics and neuroscience. She focuses her research efforts on: gene therapy for neurologic diseases; and elucidation of the role of extracellular vesicles (EVs) released from cancer cells in tumor progression. She led early studies demonstrating mutant RNA in serum EVs from glioblastoma patients as biomarkers. She did her undergraduate work at Wilson College and her graduate work in Microbial Genetics at Georgetown University. She was a Postdoctoral Fellow with Nobel Prize winner, Dr. Marshall Nirenberg at the NIH. She is currently Professor of Neurology in the Neuroscience Program at Harvard Medical School and Geneticist in the Neurology and Radiology Services at Massachusetts General Hospital.

Professor Breakefield has received a number of awards for her work, including a McKnight Foundation Neuroscience Development Award, two Javits Neuroscience Investigator Awards, the Society for Neuroscience Mika Salpeter Lifetime Achievement Award, and the Harvard Medical School William Silen Lifetime Achievement Mentoring Award. She is a member of the National Academy of Arts and Sciences and past president of the American Society of Gene and Cell Therapy.

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Extracellular Vesicles as Biomarkers and Saboteurs for Glioblastoma

Monday, 24 March 2014 at 13:45

Add to Calendar ▼2014-03-24 13:45:002014-03-24 14:45:00Europe/LondonExtracellular Vesicles as Biomarkers and Saboteurs for GlioblastomaCirculating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,

Glioblastomas are highly malignant brain tumors that have defied therapy. Extracellular vesicles released by these tumors provide a means to analyze the mutant RNA, including mutant IDH1 and EGFR, within the tumors by sampling serum/plasma and cerebral spinal fluid. These biomarkers can provide insights into the mutations driving the tumor and the response of patients to therapy, including concomitant changes in the mutation levels and profiles. These tumor vesicles are also thought to be used by gliomas to modify normal cells in their environment through extracellular delivery of RNA and proteins. Our work supports transfer of miRNA via tumor vesicles to microglia thereby participating in a change in their phenotype.

Add to Calendar ▼2014-03-24 00:00:002014-03-25 00:00:00Europe/LondonCirculating Biomarkers 2014Circulating Biomarkers 2014 in Boston, Massachusetts, USABoston, Massachusetts,