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SELECTBIO Conferences Circulating Biomarkers, Exosomes & Liquid Biopsy Asia 2019

Chwee Teck Lim's Biography

Chwee Teck Lim, NUS Society Chair Professor, Department of Biomedical Engineering, Institute for Health Innovation & Technology (iHealthtech), Mechanobiology Institute, National University of Singapore

Professor Chwee Teck LIM is the NUS Society Chair Professor of Biomedical Engineering and Director of the Institute for Health Innovation and Technology at the National University of Singapore. His research interest is in the development of microfluidic technologies for applications in disease diagnosis and health monitoring. He has co-authored over 470 journal publications and is also a serial entrepreneur having started six companies. Prof Lim is an Elected Fellow of seven academies including the US National Academy of Inventors, IUPESM, AIMBE, IAMBE, AAET, among others. He and his team have garnered numerous research awards and honours including Asia’s Most Influential Scientist, Highly Cited Researcher, Asian Scientists 100, Wall Street Journal Asian Innovation Award (Gold) and the President's Technology Award among others.

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Microfluidics Technologies for Cancer Diagnosis - From Cell Capture to Single Cell Analysis

Monday, 9 September 2019 at 11:15

Add to Calendar ▼2019-09-09 11:15:002019-09-09 12:15:00Europe/LondonMicrofluidics Technologies for Cancer Diagnosis - From Cell Capture to Single Cell AnalysisCirculating Biomarkers, Exosomes and Liquid Biopsy Asia 2019 in Seoul, KoreaSeoul,

The presence of Circulating Tumor Cells (CTCs) in bloodstream of patients is an important intermediate step in cancer metastasis and can provide valuable insights into disease detection and personalized treatment. As compared to obtaining a tissue biopsy which is invasive and painful, ‘‘liquid biopsy’’ for CTCs detection can be easily performed via a routine blood draw.  The presence and number of CTCs in peripheral blood has been associated with the severity of the disease and have potential uses for early detection, diagnosis, prognosis and treatment monitoring. However, the presence of the large number of blood cells complicates as well as makes detection of rare CTCs in blood of cancer patients extremely challenging. Here, we address these issues and demonstrate that physical biomarkers such as the unique size and deformability of CTCs can be effectively used for their detection and separation from blood via microfluidics.   We do this by leveraging on the many inherent advantages of microfluidics such as high sensitivity and spatial resolution, short processing time and low device cost. We developed a suite of microfluidic biochips that exploit the principles of cell size/deformability based separation as well as inertial focusing to perform high throughput continuous detection and separation of diseased cells.  These simple, efficient and cost effective microfluidic platforms will be invaluable in extracting viable CTCs for many downstream clinical applications including single cell analysis as well as personalized treatment.

Add to Calendar ▼2019-09-09 00:00:002019-09-10 00:00:00Europe/LondonCirculating Biomarkers, Exosomes and Liquid Biopsy Asia 2019Circulating Biomarkers, Exosomes and Liquid Biopsy Asia 2019 in Seoul, KoreaSeoul,