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SELECTBIO Conferences Sample Preparation and Analysis

Dominique PV de Kleijn's Biography

Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands

Prof. Dr. Dominique PV de Kleijn is molecular biologist and chemist and professor of Exp. Vascular Surgery at UMC Utrecht and professor at the Netherlands Heart Institute. From 2012 to 2016, he was Research Professor of Surgery at NUS/NUHS and preclinical director of the Cardiovascular Research Institute (CVRI) Singapore. He was until 2016 professor of Cardiovascular Immunology and co-chair of Experimental Cardiology at UMC Utrecht. Since 1997 he is coordinating cardiovascular research from basic science, animal myocardial infarction and atherosclerotic studies (pig and sheep) towards clinical biobanking studies. His research interests are: The innate immune system in cardiovascular disease and atherosclerosis & Biomarkers predictive for primary & secondary events with a focus on plasma extracellular vesicles. He has more then 275 publications and a H-factor of 78.

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Isolation and Characterization of Plasma Extracellular Samples from Clinical Plasma Samples

Monday, 23 March 2015 at 15:00

Add to Calendar ▼2015-03-23 11:00:002015-03-23 12:00:00Europe/LondonPlasma Extracellular Vesicle Content for Diagnosis and Prognosis of Cardiovascular

Easy, cheap, efficient and reproducible isolation of plasma extracellular vesicles is a necessity when processing large numbers of clinical samples in cohort studies.  Especially for cardiovascular disease large patient numbers are often needed to validate plasma vesicle markers to show their added value on top of risk factor models.  Classical methods like ultracentrifugation are often too time-consuming, expensive and use too large volumes of precious plasma samples.  Alternative methods suitable for larger sample numbers and smaller samples are discussed focusing on methods used in cardiovascular disease like: precipitation, column purification or flow cytometry to interrogate clinical samples with biomarkers for diagnosis and prognosis of disease.

Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonSample Preparation and