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SELECTBIO Conferences Extracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics

Aurelio Lorico's Biography

Aurelio Lorico, Professor of Pathology, Touro University Nevada School of Medicine

Aurelio Lorico, MD, PhD is Full Professor of Pathology at Touro University Nevada Medical School and Adjunct Clinical Researcher at the Mediterranean Institute of Oncology. He is an Editorial Board member of Cells. He began his scientific career as a cancer pharmacologist, working on topoisomerase II-targeted drugs with Alan Sartorelli at Yale University, where he identified MRP1 as a co-transporter of drugs and glutathione. Next, he worked on cancer gene therapy at the Norwegian Cancer Center in Oslo. Back to the US, he became intrigued with cell-cell interactions in the cancer microenvironment and extracellular vesicles (EVs). His lab studies EVs as potential diagnostic and prognostic markers in liquid biopsies from cancer patients and investigates the intracellular fate of EV-associated molecules in recipient cells. Dr. Lorico’s lab is currently also developing anti-cancer therapies based on drugs or antibodies that interfere with a novel EV intracellular pathway.

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Nuclear Transport of Extracellular Vesicles

Thursday, 25 February 2021 at 16:00

Add to Calendar ▼2021-02-25 16:00:002021-02-25 17:00:00Europe/LondonNuclear Transport of Extracellular VesiclesExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics in Virtual ConferenceVirtual

We have recently identified a novel nuclear path, where Rab7+ late endosomes enter into nuclear envelope invaginations and mediate the nuclear translocation of EV-derived biomaterials, such as proteins and RNA. The close association of three proteins; endoplasmic reticulum (ER)-localized vesicle-associated membrane protein (VAMP)-associated protein VAP-A, oxysterol-binding protein (OSBP)-related protein ORP3 and small GTPase Rab7 is essential for the entrance and/or maintenance of Rab7+ late endosomes into NEI and the nuclear transfer of EV-derived biocomponents (e.g., proteins and nucleic acids) that in turns may regulate the gene expression in host (or EV-targeted) cells (Santos et al., J. Biol. Chem. 2018).

Add to Calendar ▼2021-02-25 00:00:002021-02-26 00:00:00Europe/LondonExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and TherapeuticsExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics in Virtual ConferenceVirtual