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SELECTBIO Conferences Extracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics

Extracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics Agenda


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Thursday, 25 February 2021

00:00

Michael GranerConference Chair

Title to be Confirmed.
Michael Graner, Associate Professor, Dept of Neurosurgery, University of Colorado Anschutz School of Medicine, United States of America

00:00

Lucia LanguinoConference Chair

Title to be Confirmed.
Lucia Languino, Professor of Cancer Biology, Thomas Jefferson University, United States of America

00:00

Dominique PV de KleijnKeynote Presentation

Title to be Confirmed.
Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands, Netherlands

00:00

Jan LötvallKeynote Presentation

Title to be Confirmed.
Jan Lötvall, Professor, University of Gothenburg; Founding President of ISEV; Editor-in-Chief, Journal of Extracellular Vesicles, Sweden

00:00

My MahoneyKeynote Presentation

Title to be Confirmed.
My Mahoney, Professor and Vice Chair, Thomas Jefferson University, United States of America

00:00

Title to be Confirmed.
Aurelio Lorico, Professor of Pathology, Touro University Nevada, United States of America

00:00

Title to be Confirmed.
Johnathon Anderson, Assistant Professor, University of California Davis Health, United States of America

00:00

Fatah KashanchiKeynote Presentation

Title to be Confirmed.
Fatah Kashanchi, Professor, George Mason University, United States of America

00:00

Dolores Di VizioKeynote Presentation

Title to be Confirmed.
Dolores Di Vizio, Professor, Cedars Sinai Medical Center, United States of America

00:00

The Role of Core Facilities and Emerging Technologies in Maximizing Rigor and Reproducibility of EV Quantification and Characterization and Following MISEV Guidelines
Rachel DeRita, Director, Extracellular Vesicle Core Facility, University of Pennsylvania School of Veterinary medicine, United States of America

It remains very clear in the field of extracellular vesicle (EV) research that the rapid rate of increase in publications and expansion of interdisciplinary clinical EV interest has created the need for increased standardization and access to the appropriate technologies to uphold these standards. As the first core facility in the United States with the sole intention of creating a space where users can both isolate and characterize EVs, we provide a central location for the facilitation of EV research via access to multiple technologies (both established and emerging) such as resistive pulse sensing, nanoparticle tracking analysis, ultracentrifugation, high-performance liquid chromatography, flow cytometric analysis of EVs and additional immune or fluorescence-based EV characterization techniques.  We surveyed a group of leading scientific investigators and researchers in varying stages of their scientific careers in the Mid-Atlantic region of the US.  The survey data demonstrate applications of greatest current and future interest to be employed in a shared lab resource.  The current demand is highest for isolation services, ultracentrifugation and NTA, with a gradually increasing demand for immunophenotying analyses such as the ExoView chip array, fluorescent NTA and flow cytometry. We additionally present strategies and data-based examples of how shared resource facilities can facilitate multifactorial and rigorous EV characterization in accordance with MISEV guidelines, and encourage collaboration among EV researchers. In order to answer the larger remaining questions in the EV field such as the isolation of specific EV subsets, EV tracking between cells and the use of EVs for biomarker discovery and drug delivery, it is essential that shared resource facilities interact not only with investigators, but with each other to integrate the necessary resources to progress.

00:00

Alissa WeaverKeynote Presentation

Mechanisms of RNA Trafficking into EVs
Alissa Weaver, Cornelius Vanderbilt Professor of Cell and Developmental Biology, Vanderbilt University Medical Center, United States of America

This presentation will focus on how RNA-containing EVs are formed within cells and signaling states that regulate their formation.

00:00

How Virus Genomes and Non-Coding RNAs Regulated by RNA-binding Proteins Led to RNA Regulons that Coordinate Gene Expression
Jack Keene, James B. Duke Professor, Duke University Medical Center, United States of America

Post-transcriptional RNA regulons (PTROs) found in various cellular granules play major roles in global gene expression by coordinating the translation and localization of functionally related mRNAs and encoded proteins. The discovery of PTROs began with cloning of the first RNA-binding proteins (RBPs) in Keene lab in 1985, and their demonstrating in 1993 that RBPs bind and coordinate specific subsets of mRNAs that encode cytokine, chemokine and proto-oncogene related proteins. Keene’s paradigm of the PTRO theory was accomplished in vivo using their 2000 invention of the “RIP-seq”and “CLIP-seq” procedures. Consequently, PTROs have been shown to coordinate posttranscriptional gene expression across hundreds of biological processes in dozens of eukaryotic species.

00:00

Randolph CortelingKeynote Presentation

Title to be Confirmed.
Randolph Corteling, Head of Research, ReNeuron Ltd., United Kingdom

00:00

Designing Engineered EVs for Virus X
Chris Baldwin, Chief Commercial Officer, Exopharm Ltd., Australia

Exopharm will report on its early work of conferring tropism to exosomes using SARS-CoV-2 spike protein to deliver siRNA to impede coronavirus replication and its implication for future pandemic responses.


Agenda is not currently available
Add to Calendar ▼2021-02-25 00:00:002021-02-26 00:00:00Europe/LondonExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and TherapeuticsExtracellular Vesicles (EV)-Exosomes: Diagnostics, Delivery and Therapeutics in San Diego, CaliforniaSan Diego, CaliforniaSELECTBIOenquiries@selectbiosciences.com