Exosomic microRNAs as Orchestrators of the Biology of the Tumor MicroenvironmentSunday, 26 October 2014 at 14:30 Add to Calendar ▼2014-10-26 14:30:002014-10-26 15:30:00Europe/LondonExosomic microRNAs as Orchestrators of the Biology of the Tumor MicroenvironmentISEV2014 Educational Event in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com MicroRNAs (miRNAs) are small non-coding RNAs involved in gene expression regulation. MiRNAs are dys-regulated in almost all types of human cancers, compared to the non tumoral adjacent tissue counterpart and affect all aspects of the biology of the malignancy. Recently, it has been shown that miRNAs are also secreted by cancer cells within exosomes and can be functionally transferred from one cell to another. This original observation has led to the identification of new, unexpected mechanisms of action for exosomic miRNAs. This presentation will focus on these new functions of exosomic miRNAs, showing how cancer cells affect the surrounding tumor microenvironment by secreting exosomic miRNAs. The discovery of this exosomic-miRNA-mediated cross-talk provides the rationale for new anti-cancer approaches. |