Rheolution Webinar - Analytical and AI Guided Design of Bioinks and 3D Bioprinted Scaffolds

Overview

Join us for this FREE webinar to learn more about unique and novel methodologies that have the potential to accelerate research in tissue engineering and regenerative medicine, and ultimately their translation into clinical practices.

Formulating functional bioinks and optimizing 3D bioprinted scaffolds often involve time-consuming and costly trial and error approaches. The use of dedicated analytical testing instruments and artificial intelligence (AI) algorithms may significantly accelerate these tasks.

In this webinar, we will first introduce the ElastoSens^TM Bio, a nondestructive testing instrument that measures the viscoelasticity of soft biomaterials. We will highlight how its features can bring value to the 3D and 4D bioprinting process, from the formulation of bioinks to the design of bioprinted scaffolds and their time evolution with or without cells.

We will then present two published cases to exemplify how this technology and AI are currently helping researchers. The first work developed by a team from the University of Victoria (BC, Canada) consisted in developing protocols to measure the viscoelastic properties of 3D bioprinted scaffolds using the ElastoSens^TM Bio to help guiding the design of their architecture (in terms of fiber size, porosity, pore shape, and bioink composition). In the second work, the testing instrument was used to build a database containing the viscoelastic behavior of synthetic hydrogels (different concentrations of PEGDA) under photocrosslinking (with different light intensities). This database was then used to train a machine learning algorithm to predict the photocrosslinking kinetics of these hydrogels when selecting unknown formulations.