NGS in Clinical Genomics - Applications and Advances Agenda
Thursday, 29 November 2018
08:00
Registration
09:15
Welcome Address- Dr Sanjay Bajaj, Managing Director, Select Biosciences India
09:30
Conference Chair
Inaugural Address B R Das, Advisor & Mentor- R&D, CoE, Molecular Pathology, SRL Limited
09:40
Introduction of Resource Persons and Memento Presentation
10:00
Business Networking Session
10:10
Group Photograph
10:25
Coffee Break and Networking in Exhibition Area
Session I- NGS in Genetic Disorders and Reproductive Medicine
10:55
Next Generation Sequencing for Clinical Diagnostics: Five year Experience of an Academic Laboratory Bharat Thyagarajan, Director- Division of Molecular Pathology and Genomics & Molecular Diagnostics Clinical Laboratory (MDL), University of Minnesota
The speaker will describe how they created and implemented a single broad-based NGS sequencing assay to meet the genetic testing needs at their organization. Further, the talk will discuss about the feasibility of this broad-based NGS platform by aggregating a sufficient sample volume from many individually rare tests and providing a flexible ordering for custom, patient-specific panels.
11:25
Q/A Discussion
11:30
Next Generation Genome Diagnosis for the Multi-Disciplinary Management of Inherited Cardiovascular Conditions Dhavendra Kumar, Professor, Genomic Policy Unit, University of South Wales & Institute of Medical Genetics, Cardiff University School of Medicine
In this talk, the speaker presents their experience of managing inherited cardiomyopathies in a busy tertiary hospital heart failure clinic, as the role model for NGS diagnosis in ICC multi-disciplinary care.
12:00
Q/A Discussion
12:05
Recurrent Pregnancy Loss- Solving the Biggest Diagnostic Dilemma by Advanced Clinical Genomic Approaches Moutushy Mitra Kandalam, Director, Genomics Research and Diagnostic Services, 3i Molecular Solutions & Healthcare Services Pvt Ltd
12:35
Q/A Discussion
12:40
Next-Generation Sequencing for Noninvasive Prenatal Testing Manjeet Mehta, Director, Genetic World
13:10
Q/A Discussion
13:15
Interactive Session
13:45
Lunch and Networking in Exhibition Area
Session II- Integrating Next Generation Sequencing into Clinical Oncology
14:45
Implementation of NGS for Clinical Cancer Diagnostics Amit Dutt, Principal Investigator, Scientist F, Tata Memorial Centre
15:15
Q/A Discussion
15:20
Deep Sequencing identifies Novel Rectal Cancer Genes Murali Bashyam, Head, Molecular Oncology Lab, Centre for DNA Fingerprinting and Diagnostics
The talk will highlight how comprehensive characterization of early onset sporadic rectal cancer (EOSRC) by whole exome sequencing which detects absence of Wnt or MSI along with identification of known and novel mutational events. The study revealed several unique genetic aberrations that drive EOSRC, a CRC subtype unique to the Indian population.
15:50
Q/A Discussion
15:55
A New Perspective in Precision Oncology: Making a Case for Integrated Approaches Kshitish Acharya, Faculty Scientist, Institute of Bioinformatics & Applied Biotechnology
In this talk, the speaker intends to present some of his data and perspective on the need for an integrated approach for a more promising precision oncology where a combinatorial analysis should be performed on the mutations (classical approach: individually), haplotypes and a holistic network analysis stemming from meta analysis of transcriptomic data.
16:25
Q/A Discussion
16:30
Role of Clinical Genomics and Liquid Biopsy in Personalized Medicine Mithua Ghosh, Director- Clinical Diagnostics, Triesta Sciences, Head- Department of Molecular and Clinical Genomics, HCG Oncology
The speaker will present data and clinical case studies to establish the utility of different molecular diagnostic platforms (including multigene testing by NGS and Liquid Biopsy) in both early diagnosed and advanced cancer cases and implication of stratifying patients based on their molecular profile that could potentially benefit/not benefit from targeted therapy and chemo-radiation.
17:00
Q/A Discussion
17:05
Open Discussion and Coffee
17:30
End of First Day of the Conference
Friday, 30 November 2018
Session III- NGS in Transplant and Chronic Diseases
09:15
Novel HLA Typing Technology: Full Length Super-Resolution HLA Typing Malali Gowda, Professor, The University of Trans-Disciplinary Health Sciences and Technology
The talk will discuss how Full Length Super-Resolution HLA typing decodes HLA alleles from any individuals and populations and how Full length HLA allelic information may act as “personalized predictive health record” for an individual and save many lives.
09:45
Q/A Discussion
09:50
NGS based Comprehensive Screening in Monogenic Forms of Diabetes in India - Understanding the Diversity Aaron Chapla, Scientist- Molecular Endocrinology Laboratory, Christian Medical College and Hospital
The speaker will describe how they established and utilized a cost-effective multiplex PCR coupled NGS based approach to screen MODY genes in parallel & identify a wide spectrum of mutations in MODY along with PDX1 and NEUROD1 digenic mutations.
10:20
Q/A Discussion
10:25
Using NGS in Clinic- Clinician Perspective Anil Vasudevan, Professor and Head- Department of Pediatric Nephrology, St. John's Medical College Hospital
The speaker has developed their own NGS panels for few renal diseases (Manuscripts submitted for publication) and could discuss the utility as well as challenges and barriers to its application in a clinical setting
10:55
Q/A Discussion
11:00
Coffee Break and Networking in Exhibition Area
Session IV- NGS in Neuro and Ocular Genetics
11:30
NGS (Next Generation sequencing ) in NGS (Neuro- Genetic syndromes) - Clinical Experience from a Tertiary Care Centre Sumita Danda, Professor and Head- Clinical Genetics Unit, Christian Medical College and Hospital
12:00
Q/A Discussion
12:05
Identification of New Candidate Genes for Ocular Disorders Periasamy Sundaresan, Senior Scientist, Aravind Eye Hospital
The Presenter will discuss in detail about their experience in the field of ophthalmic genetics related to new candidate genes identified for Congenital Hereditary Endothelial Dystrophy (CHED), Pseudoexfoliation syndrome (PXF) and Primary Angle Closure Glaucoma (PACG).
12:35
Q/A Discussion
12:40
Role of Microglial mediated Inflammation in Retinopathy of Prematurity Inderjeet Kaur, Senior Scientist, LV Prasad Eye Institute
Based on comprehensive genomics and proteomics, the present will discuss how their study provided a proof of concept that tear MMP levels could serve as a potential predictor for Retinopathy of prematurity (ROP) progression in preterm babies.
13:10
Q/A Discussion
13:15
Interactive Session
13:45
Lunch and Networking in Exhibition Area
Session V- NGS and Bioinformatics Data Processing for Cancer and Infectious Diseases
14:45
Data Quality and Interpretation: Do’s and Don’ts Vamsi Veeramachaneni, Chief Scientific Officer, Strand Life Sciences
In this talk, the orator will discuss strategies for evaluating and optimising multi-step bioinformatics pipelines and will highlight how the sequencing data helps identifying common problems such as accessioning errors, cross-contamination, instrument performance degradation, NGS protocol errors etc. Finally, efficient strategies for second method evaluation that can be used to confirm these variants will be suggested.
15:15
Q/A Discussion
15:20
A Clinically Applicable Mutational Burden Threshold is a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors Kalyanasundaram Subramanian, VP Bioinformatics, Syngene
15:50
Q/A Discussion
15:55
Modeling Bacterial Chromosome Organization using Hi-C Data Farhat Habib, Director, Data Science, InMobi
The speaker will discuss about developing method using Chromosome conformation capture techniques (often abbreviated to 3C technologies or Hi-C or 3C) to obtain the 3-D organization of a genome and apply it to the C. crescentus genome.
16:25
Q/A Discussion
16:30
Impact of Alternate Data Processing Methods on Gut Microbiome Pramila Tata, Deputy Research Director, Syngene