Session 1: Flow Chemistry for Industrial Scale & API Synthesis / Session Chair: Dr. P V Srinivas
09:30
Keynote Presentation
The Use of Continuous Flow Technology Towards the Synthesis of APIs C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz
This presentation will highlight studies in the field of continuous flow processing. Emphasis will be given to highly atom efficient and process intensified chemical transformations useful for the synthesis of APIs or key intermediates that are often too hazardous to be executed in a batch reactor.
10:10
Q/A Session
10:15
Continuous Flow Synthesis: Laboratory Approach & Protocol for Scale-up Amol Kulkarni, Scientist, National Chemical Laboratory
10:50
Q/A Session
10:55
From Batch to Continuous Flow Processing: Development of Safe and Improved Methods for Aerobic Oxidation Alain Favre-Reguillon, Associate Professor, University of Lyon
This talk will highlight the advantages of continuous flow gas-liquid processes for aerobic oxidation of aldehydes and alcohols. The simple experimental setup in combination with the benefits given by continuous flow technology, including safety, renders the procedure synthetically very interesting and we will show that high throughput screening of experimental conditions resulted in the development of improved protocols.
11:30
Q/A Session
11:35
Coffee Break and Networking in Exhibition Area
Session 2: Micro & Continuous Flow Reactors and Systems / Session Chair: Dr. Luigi La Vecchia
12:05
Keynote Presentation
From Micro Reactor Research to Meso Reactor Synthesis and Production Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University
12:45
Q/A Session
12:50
Flow Chemistry Today: Towards Multistep (Enzymatic) Processes Floris Rutjes, Professor, Radboud University Nijmegen
The talk will focus on the integration of additional unit operations in a single flow system,including extraction (workup) and subsequent reaction steps to create multistep processes. Several examples will be discussed, such as enzymatic cascades, or reactions in which enzymes are combined with conventional reaction steps.
13:25
Q/A Session
13:30
Technology Spotlight: Flow Chemistry Tool Kit – Novel Technology and Chemistry including Electrochemistry in Flow Subramaniam Raman, Regional Director
13:45
Lunch Break and Networking in Exhibition Area
Session 3: Flow Reactor Scale up - Issues & Solutions / Session Chair: Dr. Ravi Sobti
14:35
Scalability of Multiphase Transport Processes using Advanced Flow Reactors Simon Kuhn, Associate Professor, Katholieke Universiteit Leuven
This talk will present a detailed experimental heat and mass transfer study of micro- and milli-scale reactors to predict the scalability of heat and mass transfer coefficients across several orders of length scale. Furthermore, a modelling strategy based on computational fluid dynamics (CFD) will be presentated which enables further design improvements of advanced flow reactors.
15:10
Q/A Session
15:15
Application of Continuous Flow Chemistry in a Pharmaceutical Environment Luigi La Vecchia, Director, Novartis Institutes for BioMedical Research
The presentation will describe the application of Continuous Flow Chemistry for scaling-up exothermic or hazardous reactions.
15:50
Q/A Session
15:55
Scalable Flow Chemistry: A Flexible Tool for the Research, Development and Production of Pharmaceuticals, Fine & Specialty Chemicals Charlotte Wiles, Chief Executive Officer, Chemtrix BV
Session 4: Process Intensification using Flow Reactors / Session Chair: Dr. Sanjay Gade
09:30
Process Intensification Utilizing High-Temperature/Pressure Flow Chemistry C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz
In this talk, the execution of a number of synthetically valuable organic transformations in a high-temperature/high-pressure continuous flow format will be described, including monophasic and multiphasic (liquid/liquid, gas/liquid) processing conditions. This presentation will also focus on Chemistry examples which includes the formation of heterocycles, transition metal-catalyzed C-C couplings, and several reduction and oxidation processes that can safely be conducted in a continuous flow environment.
Rate-based Experimental Design using Continuous Flow Reactors Christopher Hone, Research Scholar, University of Leeds
A novel methodology which implements experimental design campaigns for the generation of process rate models based on fitting a simplified kinetic motif will be presented. The rate models are then used for the optimisation and scale-up of continuous flow processes.
12:50
Q/A Session
12:55
Technology Spotlight: Integrated Liquid-Liquid Separator and its Uses in Flow Chemistry Andrea Adamo, Chief Executive Officer
13:10
Poster Evaluation
13:40
Lunch Break and Networking in Exhibition Area
Session 6: Novel Applications of Flow Chemistry / Session Chair: Dr. Oliver Kappe
14:40
Handling Slower Reactions in Flow Robert Ashe, Managing Director, AM Technology
15:15
Q/A Session
15:20
Novel Applications of Flow Chemistry in Industry and Academia Andrew Mansfield, Application Specialist, Vapourtec Ltd
15:55
Q/A Session
16:00
Photocontrolled Polymerizations in Flow: Next Generation Material Synthesis Thomas Junkers, Professor, Hasselt University
In this presentation the use of various UV sources in the copper-redox initiated controlled polymerization of (meth)acrylates will be highlighted and the efficiency of these reactions discussed with respect to the overall quality of materials that can be obtained in this pathway, ranging from multiblock copolymers to star-shaped polymeric drug carriers.