From Fragments and Hot-Spots to Novel Lead Structures

Thursday, 30 June 2011 at 09:30

Add to Calendar ▼2011-06-30 09:30:002011-06-30 10:30:00Europe/LondonFrom Fragments and Hot-Spots to Novel Lead Structures SELECTBIOenquiries@selectbiosciences.com

General experience shows that small molecule fragments, thought as initial leads for a drug design project, assemble in an ordered fashion in protein binding sites. Usually they populate at the hot spots of binding in protein surface-exposed binding pockets. Therefore, their crystallographic characterization is usually successful and the obtained structures provide a valid starting point for a subsequent optimization by growing the initially discovered fragments in the binding pocket via the decoration with suitable side chains.