SELECTBIO - In Silico Drug Discovery and Predictive Toxicology 2016 Biographies

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In Silico Framework to Account for the Interplay Between Different Mechanisms of Action for Multiple Thyroid Disruptors: A PBPK Model for Thiocyanate as a Case Study

Friday, 30 September 2016 at 09:45

Add to Calendar ▼2016-09-30 09:45:002016-09-30 10:45:00Europe/LondonIn Silico Framework to Account for the Interplay Between Different Mechanisms of Action for Multiple Thyroid Disruptors: A PBPK Model for Thiocyanate as a Case StudyIn Silico Drug Discovery and Predictive Toxicology 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com

A global pathway model for thyroid disruptors with multiple mechanisms of action is under development. A PBPK model of thiocyanate, including key sites of action in thyroid (NIS active transporter and metabolic enzyme TPO), was calibrated as an initial step.

Marie Willemin, Research Fellow, National Center for Toxicology Research, US Food and Drug administration (FDA)

Dr. Marie-Emilie WILLEMIN received her Pharmacy degree and her Master degree in Pharmacokinetics at Universite Paris Descartes (France) in 2011. She completed her PhD on the toxicokinetic modeling of the insecticide permethrin in 2014 at INERIS (National Institute of industrial environment and of the risks) (France). She is currently working as a research fellow at NCTR-US FDA (Little Rock, AR) on the prediction of the effects on the thyroid hormones of an exposure to a mixture of the environmental contaminants thiocyanate and perchlorate in pregnant women.