Therapeutic Development and Use of Exosomes in Neurological Disease and Injury

Wednesday, 3 April 2024 at 14:00

Add to Calendar ▼2024-04-03 14:00:002024-04-03 15:00:00Europe/LondonTherapeutic Development and Use of Exosomes in Neurological Disease and InjuryExtracellular Vesicles (EVs) and Nanoparticles 2024: Diagnostics, Delivery, Therapeutics in Miami, FloridaMiami, FloridaSELECTBIOenquiries@selectbiosciences.com

Exosomal vesicles (EVs) derived from neural and non-neural sources have shown potential in limiting damage to the CNS as well as promoting neurorepair. Our laboratory is interested in the development and utility of glial cell-derived exosomes as therapeutic agents in models of spinal cord injury, multiple sclerosis, and amyotrophic lateral sclerosis, among other neurological conditions. Herein I will discuss our advances in characterizing EVs from different cell sources, examining their ability to alter cellular responses in vitro in neural cell assays as well as investigating their capacity to alter pathological processes in neurological injury and disease paradigms in rodents with the goal of moving this approach towards clinical evaluation in humans.

Damien Pearse, Professor, Department of Neurological Surgery; The John M. and Jocelyn H.K. Watkins Distinguished Chair in Cell Therapies, University of Miami Miller School of Medicine

Damien Pearse

Dr. Pearse is a Professor at The Miami Project to Cure Paralysis, Department of Neurological Surgery at the University of Miami Miller School of Medicine. Dr. Pearse is also a Research Health Scientist at the Bruce Carter Miami VA Healthcare System. Dr. Pearse received his undergraduate degree in Biotechnology and doctorate in Neuroscience from Griffith University, Queensland, Australia. Following a postdoctoral fellowship at The University of Miami, Dr. Pearse joined the faculty. Dr. Pearse was an associate in the Christopher and Dana Reeve Foundation Consortium from 2000 to 2006 and in 2005 received the Erica Nader Award for being the Outstanding Investigator in SCI Research from the American Spinal Injury Association. Dr. Pearse is currently The John M. and Jocelyn H.K. Watkins Distinguished Chair in Cell Therapies where his work is focused on the translation of autologous cell therapies for neural repair following spinal cord injury and other neurological disorders.