Dr. Amber Murray received her training at MIT and The Scripps Research Institute, where she focused on protein folding and misfolding. She has spent the last several years working in biotech building tools and tests to interrogate biomarkers present in biofluids and cell culture media. In 2021, Dr. Murray co-founded Exokeryx, whose aim is to create gold-standard EV isolation and analysis tools that leverage semi-conductor technologies for automation and scalability.
Single vs Multi-Parameter EV Isolation Methods
Wednesday, 3 April 2024 at 16:00
Add to Calendar ▼2024-04-03 16:00:002024-04-03 17:00:00Europe/LondonSingle vs Multi-Parameter EV Isolation MethodsExtracellular Vesicles (EVs) and Nanoparticles 2024: Diagnostics, Delivery, Therapeutics in Miami, FloridaMiami, FloridaSELECTBIOenquiries@selectbiosciences.com
The success of extracellular vesicles (EVs) in diagnostics and therapeutics depends on scalable isolation methods that produce high recovery of highly pure EVs. Current methods for EV isolation exploit one physical property at a time—density for ultracentrifugation, size for size exclusion chromatography, presence of a given surface marker for immunoprecipitation, etc. As such, isolated EVs exhibit high recovery at the expense of purity for the cruder techniques or high purity (and bias) at the expense of recovery for the more tailored techniques. In contrast, we introduce a new EV isolation technique called dielectrophoresis that exploits two physical properties at once—particle diameter and particle composition (dipole moment) in the presence of a radio frequency electric field.
